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High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster
Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703573/ https://www.ncbi.nlm.nih.gov/pubmed/34960775 http://dx.doi.org/10.3390/v13122506 |
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author | Port, Julia R. Adney, Danielle R. Schwarz, Benjamin Schulz, Jonathan E. Sturdevant, Daniel E. Smith, Brian J. Avanzato, Victoria A. Holbrook, Myndi G. Purushotham, Jyothi N. Stromberg, Kaitlin A. Leighton, Ian Bosio, Catharine M. Shaia, Carl Munster, Vincent J. |
author_facet | Port, Julia R. Adney, Danielle R. Schwarz, Benjamin Schulz, Jonathan E. Sturdevant, Daniel E. Smith, Brian J. Avanzato, Victoria A. Holbrook, Myndi G. Purushotham, Jyothi N. Stromberg, Kaitlin A. Leighton, Ian Bosio, Catharine M. Shaia, Carl Munster, Vincent J. |
author_sort | Port, Julia R. |
collection | PubMed |
description | Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an altered, but not significantly different, systemic IL-10 and IL-6 profile, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, partially recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19. |
format | Online Article Text |
id | pubmed-8703573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87035732021-12-25 High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster Port, Julia R. Adney, Danielle R. Schwarz, Benjamin Schulz, Jonathan E. Sturdevant, Daniel E. Smith, Brian J. Avanzato, Victoria A. Holbrook, Myndi G. Purushotham, Jyothi N. Stromberg, Kaitlin A. Leighton, Ian Bosio, Catharine M. Shaia, Carl Munster, Vincent J. Viruses Article Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an altered, but not significantly different, systemic IL-10 and IL-6 profile, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, partially recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19. MDPI 2021-12-14 /pmc/articles/PMC8703573/ /pubmed/34960775 http://dx.doi.org/10.3390/v13122506 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Port, Julia R. Adney, Danielle R. Schwarz, Benjamin Schulz, Jonathan E. Sturdevant, Daniel E. Smith, Brian J. Avanzato, Victoria A. Holbrook, Myndi G. Purushotham, Jyothi N. Stromberg, Kaitlin A. Leighton, Ian Bosio, Catharine M. Shaia, Carl Munster, Vincent J. High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title_full | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title_fullStr | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title_full_unstemmed | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title_short | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
title_sort | high-fat high-sugar diet-induced changes in the lipid metabolism are associated with mildly increased covid-19 severity and delayed recovery in the syrian hamster |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703573/ https://www.ncbi.nlm.nih.gov/pubmed/34960775 http://dx.doi.org/10.3390/v13122506 |
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