Immunopathology of RSV: An Updated Review

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the curre...

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Detalles Bibliográficos
Autores principales: Bergeron, Harrison C., Tripp, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703574/
https://www.ncbi.nlm.nih.gov/pubmed/34960746
http://dx.doi.org/10.3390/v13122478
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author Bergeron, Harrison C.
Tripp, Ralph A.
author_facet Bergeron, Harrison C.
Tripp, Ralph A.
author_sort Bergeron, Harrison C.
collection PubMed
description RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.
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spelling pubmed-87035742021-12-25 Immunopathology of RSV: An Updated Review Bergeron, Harrison C. Tripp, Ralph A. Viruses Review RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection. MDPI 2021-12-10 /pmc/articles/PMC8703574/ /pubmed/34960746 http://dx.doi.org/10.3390/v13122478 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bergeron, Harrison C.
Tripp, Ralph A.
Immunopathology of RSV: An Updated Review
title Immunopathology of RSV: An Updated Review
title_full Immunopathology of RSV: An Updated Review
title_fullStr Immunopathology of RSV: An Updated Review
title_full_unstemmed Immunopathology of RSV: An Updated Review
title_short Immunopathology of RSV: An Updated Review
title_sort immunopathology of rsv: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703574/
https://www.ncbi.nlm.nih.gov/pubmed/34960746
http://dx.doi.org/10.3390/v13122478
work_keys_str_mv AT bergeronharrisonc immunopathologyofrsvanupdatedreview
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