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Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea

Significant progress has been made on the molecular biology of the severe fever with thrombopenia virus (SFTSV); however, many parts of the pathophysiological mechanisms of mortality in SFTS remain unclear. In this study, we investigated virologic and immunologic factors for fatal outcomes of patien...

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Autores principales: Kwon, Ji-Soo, Jin, Sol, Kim, Ji-Yeun, Ra, Sang-Hyun, Kim, Taeeun, Park, Se-Yoon, Kim, Min-Chul, Park, Seong-Yeon, Kim, Dasarang, Cha, Hye-Hee, Lee, Hyun-Jung, Kim, Min-Jae, Chong, Yong-Pil, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Yang-Soo, Lee, Keun-Hwa, Kee, Sun-Ho, Kim, Sung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703577/
https://www.ncbi.nlm.nih.gov/pubmed/34960620
http://dx.doi.org/10.3390/v13122351
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author Kwon, Ji-Soo
Jin, Sol
Kim, Ji-Yeun
Ra, Sang-Hyun
Kim, Taeeun
Park, Se-Yoon
Kim, Min-Chul
Park, Seong-Yeon
Kim, Dasarang
Cha, Hye-Hee
Lee, Hyun-Jung
Kim, Min-Jae
Chong, Yong-Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang-Soo
Lee, Keun-Hwa
Kee, Sun-Ho
Kim, Sung-Han
author_facet Kwon, Ji-Soo
Jin, Sol
Kim, Ji-Yeun
Ra, Sang-Hyun
Kim, Taeeun
Park, Se-Yoon
Kim, Min-Chul
Park, Seong-Yeon
Kim, Dasarang
Cha, Hye-Hee
Lee, Hyun-Jung
Kim, Min-Jae
Chong, Yong-Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang-Soo
Lee, Keun-Hwa
Kee, Sun-Ho
Kim, Sung-Han
author_sort Kwon, Ji-Soo
collection PubMed
description Significant progress has been made on the molecular biology of the severe fever with thrombopenia virus (SFTSV); however, many parts of the pathophysiological mechanisms of mortality in SFTS remain unclear. In this study, we investigated virologic and immunologic factors for fatal outcomes of patients with SFTS. We prospectively enrolled SFTS patients admitted from July 2015 to October 2020. Plasma samples were subjected to SFTSV RNA RT-PCR, multiplex microbead immunoassay for 17 cytokines, and IFA assay. A total of 44 SFTS patients were enrolled, including 37 (84.1%) survivors and 7 (15.9%) non-survivors. Non-survivors had a 2.5 times higher plasma SFTSV load than survivors at admission (p < 0.001), and the viral load in non-survivors increased progressively during hospitalization. In addition, non-survivors did not develop adequate anti-SFTSV IgG, whereas survivors exhibited anti-SFTSV IgG during hospitalization. IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF were significantly elevated in non-survivors compared to survivors and did not revert to normal ranges during hospitalization (p < 0.05). Severe signs of inflammation such as a high plasma concentration of IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF, poor viral control, and inadequate antibody response during the disease course were associated with mortality in SFTS patients.
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spelling pubmed-87035772021-12-25 Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea Kwon, Ji-Soo Jin, Sol Kim, Ji-Yeun Ra, Sang-Hyun Kim, Taeeun Park, Se-Yoon Kim, Min-Chul Park, Seong-Yeon Kim, Dasarang Cha, Hye-Hee Lee, Hyun-Jung Kim, Min-Jae Chong, Yong-Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang-Soo Lee, Keun-Hwa Kee, Sun-Ho Kim, Sung-Han Viruses Article Significant progress has been made on the molecular biology of the severe fever with thrombopenia virus (SFTSV); however, many parts of the pathophysiological mechanisms of mortality in SFTS remain unclear. In this study, we investigated virologic and immunologic factors for fatal outcomes of patients with SFTS. We prospectively enrolled SFTS patients admitted from July 2015 to October 2020. Plasma samples were subjected to SFTSV RNA RT-PCR, multiplex microbead immunoassay for 17 cytokines, and IFA assay. A total of 44 SFTS patients were enrolled, including 37 (84.1%) survivors and 7 (15.9%) non-survivors. Non-survivors had a 2.5 times higher plasma SFTSV load than survivors at admission (p < 0.001), and the viral load in non-survivors increased progressively during hospitalization. In addition, non-survivors did not develop adequate anti-SFTSV IgG, whereas survivors exhibited anti-SFTSV IgG during hospitalization. IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF were significantly elevated in non-survivors compared to survivors and did not revert to normal ranges during hospitalization (p < 0.05). Severe signs of inflammation such as a high plasma concentration of IFN-α, IL-10, IP-10, IFN-γ, IL-6, IL-8, MCP-1, MIP-1α, and G-CSF, poor viral control, and inadequate antibody response during the disease course were associated with mortality in SFTS patients. MDPI 2021-11-23 /pmc/articles/PMC8703577/ /pubmed/34960620 http://dx.doi.org/10.3390/v13122351 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Ji-Soo
Jin, Sol
Kim, Ji-Yeun
Ra, Sang-Hyun
Kim, Taeeun
Park, Se-Yoon
Kim, Min-Chul
Park, Seong-Yeon
Kim, Dasarang
Cha, Hye-Hee
Lee, Hyun-Jung
Kim, Min-Jae
Chong, Yong-Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang-Soo
Lee, Keun-Hwa
Kee, Sun-Ho
Kim, Sung-Han
Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title_full Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title_fullStr Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title_full_unstemmed Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title_short Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
title_sort viral and immunologic factors associated with fatal outcome of patients with severe fever with thrombocytopenia syndrome in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703577/
https://www.ncbi.nlm.nih.gov/pubmed/34960620
http://dx.doi.org/10.3390/v13122351
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