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Three-Dimensional Semantic Segmentation of Pituitary Adenomas Based on the Deep Learning Framework-nnU-Net: A Clinical Perspective

This study developed and evaluated nnU-Net models for three-dimensional semantic segmentation of pituitary adenomas (PAs) from contrast-enhanced T1 (T1ce) images, with aims to train a deep learning-based model cost-effectively and apply it to clinical practice. Methods: This study was conducted in t...

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Detalles Bibliográficos
Autores principales: Shu, Xujun, Zhou, Yijie, Li, Fangye, Zhou, Tao, Meng, Xianghui, Wang, Fuyu, Zhang, Zhizhong, Pu, Jian, Xu, Bainan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703586/
https://www.ncbi.nlm.nih.gov/pubmed/34945322
http://dx.doi.org/10.3390/mi12121473
Descripción
Sumario:This study developed and evaluated nnU-Net models for three-dimensional semantic segmentation of pituitary adenomas (PAs) from contrast-enhanced T1 (T1ce) images, with aims to train a deep learning-based model cost-effectively and apply it to clinical practice. Methods: This study was conducted in two phases. In phase one, two models were trained with nnUNet using distinct PA datasets. Model 1 was trained with 208 PAs in total, and model 2 was trained with 109 primary nonfunctional pituitary adenomas (NFPA). In phase two, the performances of the two models were investigated according to the Dice similarity coefficient (DSC) in the leave-out test dataset. Results: Both models performed well (DSC > 0.8) for PAs with volumes > 1000 mm(3), but unsatisfactorily (DSC < 0.5) for PAs < 1000 mm(3). Conclusions: Both nnU-Net models showed good segmentation performance for PAs > 1000 mm(3) (75% of the dataset) and limited performance for PAs < 1000 mm(3) (25% of the dataset). Model 2 trained with fewer samples was more cost-effective. We propose to combine the use of model-based segmentation for PA > 1000 mm(3) and manual segmentation for PA < 1000 mm(3) in clinical practice at the current stage.