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Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications
Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703599/ https://www.ncbi.nlm.nih.gov/pubmed/34960918 http://dx.doi.org/10.3390/polym13244368 |
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author | Mbese, Zintle Alven, Sibusiso Aderibigbe, Blessing Atim |
author_facet | Mbese, Zintle Alven, Sibusiso Aderibigbe, Blessing Atim |
author_sort | Mbese, Zintle |
collection | PubMed |
description | Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing. |
format | Online Article Text |
id | pubmed-8703599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87035992021-12-25 Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications Mbese, Zintle Alven, Sibusiso Aderibigbe, Blessing Atim Polymers (Basel) Review Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing. MDPI 2021-12-13 /pmc/articles/PMC8703599/ /pubmed/34960918 http://dx.doi.org/10.3390/polym13244368 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mbese, Zintle Alven, Sibusiso Aderibigbe, Blessing Atim Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title | Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title_full | Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title_fullStr | Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title_full_unstemmed | Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title_short | Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications |
title_sort | collagen-based nanofibers for skin regeneration and wound dressing applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703599/ https://www.ncbi.nlm.nih.gov/pubmed/34960918 http://dx.doi.org/10.3390/polym13244368 |
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