Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new...

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Autores principales: Long, Jieyi, Chen, Yaqi, Chen, Weihao, Wang, Junfeng, Zhou, Xuefeng, Yang, Bin, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703611/
https://www.ncbi.nlm.nih.gov/pubmed/34940700
http://dx.doi.org/10.3390/md19120701
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author Long, Jieyi
Chen, Yaqi
Chen, Weihao
Wang, Junfeng
Zhou, Xuefeng
Yang, Bin
Liu, Yonghong
author_facet Long, Jieyi
Chen, Yaqi
Chen, Weihao
Wang, Junfeng
Zhou, Xuefeng
Yang, Bin
Liu, Yonghong
author_sort Long, Jieyi
collection PubMed
description Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC(50) value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC(50) value of 10.1 μM.
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spelling pubmed-87036112021-12-25 Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031 Long, Jieyi Chen, Yaqi Chen, Weihao Wang, Junfeng Zhou, Xuefeng Yang, Bin Liu, Yonghong Mar Drugs Article Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC(50) value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC(50) value of 10.1 μM. MDPI 2021-12-10 /pmc/articles/PMC8703611/ /pubmed/34940700 http://dx.doi.org/10.3390/md19120701 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Jieyi
Chen, Yaqi
Chen, Weihao
Wang, Junfeng
Zhou, Xuefeng
Yang, Bin
Liu, Yonghong
Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title_full Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title_fullStr Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title_full_unstemmed Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title_short Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031
title_sort cyclic peptides from the soft coral-derived fungus aspergillus sclerotiorum scsio 41031
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703611/
https://www.ncbi.nlm.nih.gov/pubmed/34940700
http://dx.doi.org/10.3390/md19120701
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