Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation

Huntington’s disease (HD) is one of at least nine polyglutamine diseases caused by a trinucleotide CAG repeat expansion, all of which lead to age-onset neurodegeneration. Mitochondrial dynamics and function are disrupted in HD and other polyglutamine diseases. While multiple studies have found benef...

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Detalles Bibliográficos
Autores principales: Traa, Annika, Machiela, Emily, Rudich, Paige D., Soo, Sonja K., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703635/
https://www.ncbi.nlm.nih.gov/pubmed/34948242
http://dx.doi.org/10.3390/ijms222413447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703635/
https://www.ncbi.nlm.nih.gov/pubmed/34948242
http://dx.doi.org/10.3390/ijms222413447

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