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Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection

Large variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, fro...

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Autores principales: Moreira, Ana C., Teles, Maria Jose, Silva, Tânia, Bento, Clara M., Alves, Inês Simões, Pereira, Luisa, Guimarães, João Tiago, Porto, Graça, Oliveira, Pedro, Gomes, Maria Salomé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703662/
https://www.ncbi.nlm.nih.gov/pubmed/34960751
http://dx.doi.org/10.3390/v13122482
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author Moreira, Ana C.
Teles, Maria Jose
Silva, Tânia
Bento, Clara M.
Alves, Inês Simões
Pereira, Luisa
Guimarães, João Tiago
Porto, Graça
Oliveira, Pedro
Gomes, Maria Salomé
author_facet Moreira, Ana C.
Teles, Maria Jose
Silva, Tânia
Bento, Clara M.
Alves, Inês Simões
Pereira, Luisa
Guimarães, João Tiago
Porto, Graça
Oliveira, Pedro
Gomes, Maria Salomé
author_sort Moreira, Ana C.
collection PubMed
description Large variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative. Iron-related laboratory parameters and cytokines were determined in blood samples collected soon after admission. Demographic data, comorbidities and clinical outcomes were recorded. Patients were assigned into five groups according to severity. Serum iron and transferrin levels at admission were lower in COVID-19-positive than in COVID-19-negative patients. The levels of interleukin (IL)-6 and monocyte chemoattractant protein 1 (MCP-1) were increased in COVID-19-positive patients. The lowest serum iron and transferrin levels at diagnosis were associated with the worst outcomes. Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis. Serum ferritin levels at diagnosis were higher in COVID-19-positive than in COVID-19-negative patients. Serum iron is the simplest laboratory test to be implemented as a predictor of disease progression in COVID-19-positive patients.
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spelling pubmed-87036622021-12-25 Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection Moreira, Ana C. Teles, Maria Jose Silva, Tânia Bento, Clara M. Alves, Inês Simões Pereira, Luisa Guimarães, João Tiago Porto, Graça Oliveira, Pedro Gomes, Maria Salomé Viruses Article Large variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative. Iron-related laboratory parameters and cytokines were determined in blood samples collected soon after admission. Demographic data, comorbidities and clinical outcomes were recorded. Patients were assigned into five groups according to severity. Serum iron and transferrin levels at admission were lower in COVID-19-positive than in COVID-19-negative patients. The levels of interleukin (IL)-6 and monocyte chemoattractant protein 1 (MCP-1) were increased in COVID-19-positive patients. The lowest serum iron and transferrin levels at diagnosis were associated with the worst outcomes. Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis. Serum ferritin levels at diagnosis were higher in COVID-19-positive than in COVID-19-negative patients. Serum iron is the simplest laboratory test to be implemented as a predictor of disease progression in COVID-19-positive patients. MDPI 2021-12-10 /pmc/articles/PMC8703662/ /pubmed/34960751 http://dx.doi.org/10.3390/v13122482 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moreira, Ana C.
Teles, Maria Jose
Silva, Tânia
Bento, Clara M.
Alves, Inês Simões
Pereira, Luisa
Guimarães, João Tiago
Porto, Graça
Oliveira, Pedro
Gomes, Maria Salomé
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title_full Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title_fullStr Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title_full_unstemmed Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title_short Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
title_sort iron related biomarkers predict disease severity in a cohort of portuguese adult patients during covid-19 acute infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703662/
https://www.ncbi.nlm.nih.gov/pubmed/34960751
http://dx.doi.org/10.3390/v13122482
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