Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70

Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. Such structures, presenting up to five diversity centers, have allowed the synthesis of a wide ran...

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Detalles Bibliográficos
Autores principales: Masip, Victor, Lirio, Ángel, Sánchez-López, Albert, Cuenca, Ana B., Puig de la Bellacasa, Raimon, Abrisqueta, Pau, Teixidó, Jordi, Borrell, José I., Gibert, Albert, Estrada-Tejedor, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703703/
https://www.ncbi.nlm.nih.gov/pubmed/34959711
http://dx.doi.org/10.3390/ph14121311

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