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Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10

Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with...

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Autores principales: Alexandre, Andrea M., Valente, Iacopo, Consoli, Arturo, Trombatore, Pietro, Scarcia, Luca, Piano, Mariangela, Limbucci, Nicola, Gabrieli, Joseph Domenico, Russo, Riccardo, Caragliano, Antonio Armando, Ruggiero, Maria, Saletti, Andrea, Lazzarotti, Guido Andrea, Pileggi, Marco, Cosottini, Mirco, Pilato, Fabio, Slomka, Artur, Colò, Francesca, Giubbolini, Francesca, Frisullo, Giovanni, Della Marca, Giacomo, Broccolini, Aldobrando, Pedicelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703711/
https://www.ncbi.nlm.nih.gov/pubmed/34947955
http://dx.doi.org/10.3390/life11121423
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author Alexandre, Andrea M.
Valente, Iacopo
Consoli, Arturo
Trombatore, Pietro
Scarcia, Luca
Piano, Mariangela
Limbucci, Nicola
Gabrieli, Joseph Domenico
Russo, Riccardo
Caragliano, Antonio Armando
Ruggiero, Maria
Saletti, Andrea
Lazzarotti, Guido Andrea
Pileggi, Marco
Cosottini, Mirco
Pilato, Fabio
Slomka, Artur
Colò, Francesca
Giubbolini, Francesca
Frisullo, Giovanni
Della Marca, Giacomo
Broccolini, Aldobrando
Pedicelli, Alessandro
author_facet Alexandre, Andrea M.
Valente, Iacopo
Consoli, Arturo
Trombatore, Pietro
Scarcia, Luca
Piano, Mariangela
Limbucci, Nicola
Gabrieli, Joseph Domenico
Russo, Riccardo
Caragliano, Antonio Armando
Ruggiero, Maria
Saletti, Andrea
Lazzarotti, Guido Andrea
Pileggi, Marco
Cosottini, Mirco
Pilato, Fabio
Slomka, Artur
Colò, Francesca
Giubbolini, Francesca
Frisullo, Giovanni
Della Marca, Giacomo
Broccolini, Aldobrando
Pedicelli, Alessandro
author_sort Alexandre, Andrea M.
collection PubMed
description Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with mild neurological symptoms. The database of 10 high-volume stroke centers in Europe, including a period of three year and a half, was screened for patients with an acute basilar artery occlusion or a single dominant vertebral artery occlusion (“functional” BAO) presenting with a NIHSS ≤10, and with at least 3 months follow-up. A total of 63 patients were included. Multivariate analysis demonstrated that female gender (adjusted OR 0.04; 95% CI 0–0.84; p = 0.04) and combined technique (adj OR 0.001; 95% CI 0–0.81; p = 0.04) were predictors of worse outcome. Higher pc-ASPECTS (adj OR 4.75; 95% CI 1.33–16.94; p = 0.02) and higher Delta NIHSS (adj OR 2.06; 95% CI 1.16–3.65; p = 0.01) were predictors of better outcome. Delta NIHSS was the main predictor of good outcome at 90 days in patients with posterior circulation LVO presenting with NIHSS score ≤ 10.
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spelling pubmed-87037112021-12-25 Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 Alexandre, Andrea M. Valente, Iacopo Consoli, Arturo Trombatore, Pietro Scarcia, Luca Piano, Mariangela Limbucci, Nicola Gabrieli, Joseph Domenico Russo, Riccardo Caragliano, Antonio Armando Ruggiero, Maria Saletti, Andrea Lazzarotti, Guido Andrea Pileggi, Marco Cosottini, Mirco Pilato, Fabio Slomka, Artur Colò, Francesca Giubbolini, Francesca Frisullo, Giovanni Della Marca, Giacomo Broccolini, Aldobrando Pedicelli, Alessandro Life (Basel) Article Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with mild neurological symptoms. The database of 10 high-volume stroke centers in Europe, including a period of three year and a half, was screened for patients with an acute basilar artery occlusion or a single dominant vertebral artery occlusion (“functional” BAO) presenting with a NIHSS ≤10, and with at least 3 months follow-up. A total of 63 patients were included. Multivariate analysis demonstrated that female gender (adjusted OR 0.04; 95% CI 0–0.84; p = 0.04) and combined technique (adj OR 0.001; 95% CI 0–0.81; p = 0.04) were predictors of worse outcome. Higher pc-ASPECTS (adj OR 4.75; 95% CI 1.33–16.94; p = 0.02) and higher Delta NIHSS (adj OR 2.06; 95% CI 1.16–3.65; p = 0.01) were predictors of better outcome. Delta NIHSS was the main predictor of good outcome at 90 days in patients with posterior circulation LVO presenting with NIHSS score ≤ 10. MDPI 2021-12-17 /pmc/articles/PMC8703711/ /pubmed/34947955 http://dx.doi.org/10.3390/life11121423 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alexandre, Andrea M.
Valente, Iacopo
Consoli, Arturo
Trombatore, Pietro
Scarcia, Luca
Piano, Mariangela
Limbucci, Nicola
Gabrieli, Joseph Domenico
Russo, Riccardo
Caragliano, Antonio Armando
Ruggiero, Maria
Saletti, Andrea
Lazzarotti, Guido Andrea
Pileggi, Marco
Cosottini, Mirco
Pilato, Fabio
Slomka, Artur
Colò, Francesca
Giubbolini, Francesca
Frisullo, Giovanni
Della Marca, Giacomo
Broccolini, Aldobrando
Pedicelli, Alessandro
Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title_full Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title_fullStr Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title_full_unstemmed Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title_short Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
title_sort posterior circulation endovascular thrombectomy for large vessels occlusion in patients presenting with nihss score ≤ 10
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703711/
https://www.ncbi.nlm.nih.gov/pubmed/34947955
http://dx.doi.org/10.3390/life11121423
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