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Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10
Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703711/ https://www.ncbi.nlm.nih.gov/pubmed/34947955 http://dx.doi.org/10.3390/life11121423 |
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author | Alexandre, Andrea M. Valente, Iacopo Consoli, Arturo Trombatore, Pietro Scarcia, Luca Piano, Mariangela Limbucci, Nicola Gabrieli, Joseph Domenico Russo, Riccardo Caragliano, Antonio Armando Ruggiero, Maria Saletti, Andrea Lazzarotti, Guido Andrea Pileggi, Marco Cosottini, Mirco Pilato, Fabio Slomka, Artur Colò, Francesca Giubbolini, Francesca Frisullo, Giovanni Della Marca, Giacomo Broccolini, Aldobrando Pedicelli, Alessandro |
author_facet | Alexandre, Andrea M. Valente, Iacopo Consoli, Arturo Trombatore, Pietro Scarcia, Luca Piano, Mariangela Limbucci, Nicola Gabrieli, Joseph Domenico Russo, Riccardo Caragliano, Antonio Armando Ruggiero, Maria Saletti, Andrea Lazzarotti, Guido Andrea Pileggi, Marco Cosottini, Mirco Pilato, Fabio Slomka, Artur Colò, Francesca Giubbolini, Francesca Frisullo, Giovanni Della Marca, Giacomo Broccolini, Aldobrando Pedicelli, Alessandro |
author_sort | Alexandre, Andrea M. |
collection | PubMed |
description | Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with mild neurological symptoms. The database of 10 high-volume stroke centers in Europe, including a period of three year and a half, was screened for patients with an acute basilar artery occlusion or a single dominant vertebral artery occlusion (“functional” BAO) presenting with a NIHSS ≤10, and with at least 3 months follow-up. A total of 63 patients were included. Multivariate analysis demonstrated that female gender (adjusted OR 0.04; 95% CI 0–0.84; p = 0.04) and combined technique (adj OR 0.001; 95% CI 0–0.81; p = 0.04) were predictors of worse outcome. Higher pc-ASPECTS (adj OR 4.75; 95% CI 1.33–16.94; p = 0.02) and higher Delta NIHSS (adj OR 2.06; 95% CI 1.16–3.65; p = 0.01) were predictors of better outcome. Delta NIHSS was the main predictor of good outcome at 90 days in patients with posterior circulation LVO presenting with NIHSS score ≤ 10. |
format | Online Article Text |
id | pubmed-8703711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87037112021-12-25 Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 Alexandre, Andrea M. Valente, Iacopo Consoli, Arturo Trombatore, Pietro Scarcia, Luca Piano, Mariangela Limbucci, Nicola Gabrieli, Joseph Domenico Russo, Riccardo Caragliano, Antonio Armando Ruggiero, Maria Saletti, Andrea Lazzarotti, Guido Andrea Pileggi, Marco Cosottini, Mirco Pilato, Fabio Slomka, Artur Colò, Francesca Giubbolini, Francesca Frisullo, Giovanni Della Marca, Giacomo Broccolini, Aldobrando Pedicelli, Alessandro Life (Basel) Article Mechanical thrombectomy (MT) is currently the gold standard treatment for ischemic stroke due to large vessel occlusion (LVO). However, the evidence of clinical usefulness of MT in posterior circulation LVO (pc-LVO) is still doubtful compared to the anterior circulation, especially in patients with mild neurological symptoms. The database of 10 high-volume stroke centers in Europe, including a period of three year and a half, was screened for patients with an acute basilar artery occlusion or a single dominant vertebral artery occlusion (“functional” BAO) presenting with a NIHSS ≤10, and with at least 3 months follow-up. A total of 63 patients were included. Multivariate analysis demonstrated that female gender (adjusted OR 0.04; 95% CI 0–0.84; p = 0.04) and combined technique (adj OR 0.001; 95% CI 0–0.81; p = 0.04) were predictors of worse outcome. Higher pc-ASPECTS (adj OR 4.75; 95% CI 1.33–16.94; p = 0.02) and higher Delta NIHSS (adj OR 2.06; 95% CI 1.16–3.65; p = 0.01) were predictors of better outcome. Delta NIHSS was the main predictor of good outcome at 90 days in patients with posterior circulation LVO presenting with NIHSS score ≤ 10. MDPI 2021-12-17 /pmc/articles/PMC8703711/ /pubmed/34947955 http://dx.doi.org/10.3390/life11121423 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alexandre, Andrea M. Valente, Iacopo Consoli, Arturo Trombatore, Pietro Scarcia, Luca Piano, Mariangela Limbucci, Nicola Gabrieli, Joseph Domenico Russo, Riccardo Caragliano, Antonio Armando Ruggiero, Maria Saletti, Andrea Lazzarotti, Guido Andrea Pileggi, Marco Cosottini, Mirco Pilato, Fabio Slomka, Artur Colò, Francesca Giubbolini, Francesca Frisullo, Giovanni Della Marca, Giacomo Broccolini, Aldobrando Pedicelli, Alessandro Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title | Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title_full | Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title_fullStr | Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title_full_unstemmed | Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title_short | Posterior Circulation Endovascular Thrombectomy for Large Vessels Occlusion in Patients Presenting with NIHSS Score ≤ 10 |
title_sort | posterior circulation endovascular thrombectomy for large vessels occlusion in patients presenting with nihss score ≤ 10 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703711/ https://www.ncbi.nlm.nih.gov/pubmed/34947955 http://dx.doi.org/10.3390/life11121423 |
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