Cargando…

Novel Bispidine-Monoterpene Conjugates—Synthesis and Application as Ligands for the Catalytic Ethylation of Chalcones

A number of new chiral bispidines containing monoterpenoid fragments have been obtained. The bispidines were studied as ligands for Ni-catalyzed addition of diethylzinc to chalcones. The conditions for chromatographic analysis by HPLC-UV were developed, in which the peaks of the enantiomers of all s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suslov, Evgeniy V., Ponomarev, Konstantin Y., Patrusheva, Oxana S., Kuranov, Sergey O., Okhina, Alina A., Rogachev, Artem D., Munkuev, Aldar A., Ottenbacher, Roman V., Dalinger, Alexander I., Kalinin, Mikhail A., Vatsadze, Sergey Z., Volcho, Konstantin P., Salakhutdinov, Nariman F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703799/ https://www.ncbi.nlm.nih.gov/pubmed/34946622 http://dx.doi.org/10.3390/molecules26247539

Ejemplares similares

Bispidine Platform as a Tool for Studying Amide Configuration Stability
por: Krut’ko, Dmitry P., et al.
Publicado: (2022)

Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer’s Disease Based on Novel Monoterpene-Derived Hydroxamic Acids
por: Aleksandrova, Yulia, et al.
Publicado: (2023)

Hydroxamic Acids Containing a Bicyclic Pinane Backbone as Epigenetic and Metabolic Regulators: Synergizing Agents to Overcome Cisplatin Resistance
por: Aleksandrova, Yulia, et al.
Publicado: (2023)

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments
por: Munkuev, Aldar A., et al.
Publicado: (2021)

Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors
por: Shcherbakov, Dmitriy, et al.
Publicado: (2021)

Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer’s Disease: Synthesis, Docking and Biological Evaluation
por: Neganova, Margarita, et al.
Publicado: (2021)

Copper–Bispidine Complexes: Synthesis and Complex Stability Study
por: Medved’ko, Aleksei V., et al.
Publicado: (2016)

New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model
por: Dragomanova, Stela, et al.
Publicado: (2022)

Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin–Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus
por: Nemolochnova, Arina G., et al.
Publicado: (2022)

Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
por: Khomenko, Tatyana M., et al.
Publicado: (2021)

New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins
por: Khomenko, Tatyana M., et al.
Publicado: (2023)

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan
por: Munkuev, Aldar A., et al.
Publicado: (2022)

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
por: Kuranov, Sergey, et al.
Publicado: (2022)

Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity
por: Li-Zhulanov, Nikolai S., et al.
Publicado: (2023)

Azaadamantanes, a New Promising Scaffold for Medical Chemistry
por: Suslov, E. V., et al.
Publicado: (2021)

Neuroregeneration in Parkinson’s Disease: From Proteins to Small Molecules
por: Sidorova, Yulia A., et al.
Publicado: (2019)

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties
por: Ivankin, Dmitry I., et al.
Publicado: (2023)

A practical way to synthesize chiral fluoro-containing polyhydro-2H-chromenes from monoterpenoids
por: Mikhalchenko, Oksana S, et al.
Publicado: (2016)

A New Stereoselective Approach to the Substitution of Allyl Hydroxy Group in para-Mentha-1,2-diol in the Search for New Antiparkinsonian Agents
por: Podturkina, Alexandra V., et al.
Publicado: (2023)

Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo
por: Markov, Andrey V., et al.
Publicado: (2022)

Therapeutic Potential of Myrtenal and Its Derivatives—A Review
por: Dragomanova, Stela, et al.
Publicado: (2023)

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines
por: Neborak, Ekaterina V., et al.
Publicado: (2022)

Synthesis of non-symmetric N-benzylbispidinol amides and study of their inhibitory activity against the main protease of the SARS-CoV-2 virus
por: Dalinger, A. I., et al.
Publicado: (2023)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson’s Disease Model by Alleviating Mitochondrial Dysfunction
por: Aleksandrova, Yulia, et al.
Publicado: (2023)

Selective Preparation of trans-Carveol over Ceria Supported Mesoporous Materials MCM-41 and SBA-15
por: Stekrova, Martina, et al.
Publicado: (2013)

On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153
por: Moskaliuk, Vitalii S., et al.
Publicado: (2023)

Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development
por: Telegina, Darya V., et al.
Publicado: (2020)

Synthesis and Evaluation of Hypoglycemic Activity of Structural Isomers of ((Benzyloxy)phenyl)propanoic Acid Bearing an Aminobornyl Moiety
por: Kuranov, Sergey O., et al.
Publicado: (2023)

syn-3-(4-Chlorobenzyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol
por: Kudryavtsev, Konstantin V., et al.
Publicado: (2012)

Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
por: Pon`kina, Darya, et al.
Publicado: (2023)

Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome
por: Blokhin, Mikhail E., et al.
Publicado: (2023)

Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
por: Kuranov, Sergey, et al.
Publicado: (2020)

Bornyl-Containing Derivatives of Benzyloxyphenylpropanoic Acid as FFAR1 Agonists: In Vitro and In Vivo Studies
por: Pon’kina, Darya A., et al.
Publicado: (2023)

A Newly Identified Monoterpenoid-Based Small Molecule Able to Support the Survival of Primary Cultured Dopamine Neurons and Alleviate MPTP-Induced Toxicity In Vivo
por: Kotliarova, Anastasiia, et al.
Publicado: (2022)

First‐Generation Bispidine Chelators for (213)Bi(III) Radiopharmaceutical Applications
por: Bruchertseifer, Frank, et al.
Publicado: (2020)

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors
por: Mozhaitsev, Evgenii S., et al.
Publicado: (2022)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

Versatile Bispidine‐Based Bifunctional Chelators for (64)Cu(II)‐Labelling of Biomolecules
por: Singh, Garima, et al.
Publicado: (2020)

Pathways of the Extremely Reactive Iron(IV)‐oxido complexes with Tetradentate Bispidine Ligands
por: Abu‐Odeh, Mahmud, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_na2fvvnhhvq2f9v3ig08ilsmho