Cargando…

Zearalenone Exposure Disrupts Blood–Testis Barrier Integrity through Excessive Ca(2+)-Mediated Autophagy

Zearalenone (ZEA), a common mycotoxin in grains and animal feeds, has been associated with male reproductive disorders. However, the potential toxicity mechanism of ZEA is not fully understood. In this study, in vivo and in vitro models were used to explore the effects of ZEA on the blood–testis bar...

Descripción completa

Detalles Bibliográficos
Autores principales:	She, Jinjin, Feng, Nannan, Zheng, Wanglong, Zheng, Hao, Cai, Peirong, Zou, Hui, Yuan, Yan, Gu, Jianhong, Liu, Zongping, Bian, Jianchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703826/ https://www.ncbi.nlm.nih.gov/pubmed/34941713 http://dx.doi.org/10.3390/toxins13120875

Ejemplares similares

Treatment with, Resveratrol, a SIRT1 Activator, Prevents Zearalenone-Induced Lactic Acid Metabolism Disorder in Rat Sertoli Cells
por: Cai, Peirong, et al.
Publicado: (2019)

The Role of miRNAs in Zearalenone-Promotion of TM3 Cell Proliferation
por: Zheng, Wanglong, et al.
Publicado: (2019)

Zearalenone Promotes Cell Proliferation or Causes Cell Death?
por: Zheng, Wanglong, et al.
Publicado: (2018)

Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway
por: Feng, Nannan, et al.
Publicado: (2023)

Zearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells
por: Zheng, Wanglong, et al.
Publicado: (2018)

Author Correction: Zearalenone altered the cytoskeletal structure via ER stress– autophagy– oxidative stress pathway in mouse TM4 Sertoli cells
por: Zheng, Wanglong, et al.
Publicado: (2020)

Molecular Mechanism of Aflatoxin-Induced Hepatocellular Carcinoma Derived from a Bioinformatics Analysis
por: Cai, Peirong, et al.
Publicado: (2020)

Role of PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway in Resveratrol Alleviation of Zearalenone-Induced Oxidative Stress and Apoptosis in TM4 Cells
por: Xu, Wenlin, et al.
Publicado: (2022)

Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts
por: Liu, Wei, et al.
Publicado: (2016)

Overexpression of c‐Fos reverses osteoprotegerin‐mediated suppression of osteoclastogenesis by increasing the Beclin1‐induced autophagy
por: Tong, Xishuai, et al.
Publicado: (2020)

Taurine Alleviates Cadmium-Induced Hepatotoxicity by Regulating Autophagy Flux
por: Duan, Yuntian, et al.
Publicado: (2023)

DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy
por: Yi, W.E.I., et al.
Publicado: (2018)

Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy
por: Li, Dan, et al.
Publicado: (2020)

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes
por: Wang, Tao, et al.
Publicado: (2021)

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in Autophagy
por: Zheng, Wanglong, et al.
Publicado: (2021)

The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence
por: Wang, Tao, et al.
Publicado: (2016)

Zearalenone Degradation by Dielectric Barrier Discharge Cold Plasma: The Kinetics and Mechanism
por: Zheng, Zhe, et al.
Publicado: (2022)

Suppression of AMP‐activated protein kinase reverses osteoprotegerin‐induced inhibition of osteoclast differentiation by reducing autophagy
por: Tong, Xishuai, et al.
Publicado: (2019)

Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells
por: Hu, Di, et al.
Publicado: (2016)

Disruption of microtubules in plants suppresses macroautophagy and triggers starch excess-associated chloroplast autophagy
por: Wang, Yan, et al.
Publicado: (2015)

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture
por: Liu, Gang, et al.
Publicado: (2017)

COVID-19 disrupts the blood–testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins
por: Peirouvi, Tahmineh, et al.
Publicado: (2021)

Zearalenone Exposure Disrupts STAT-ISG15 in Rat Colon: A Potential Linkage between Zearalenone and Inflammatory Bowel Disease
por: Ruan, Haonan, et al.
Publicado: (2023)

Spinal Cord Injury Causes Sustained Disruption of the Blood-Testis Barrier in the Rat
por: Dulin, Jennifer N., et al.
Publicado: (2011)

Zearalenone Induces Apoptosis and Autophagy in a Spermatogonia Cell Line
por: Lee, Ran, et al.
Publicado: (2022)

In silico methods for metabolomic and toxicity prediction of zearalenone, α-zearalenone and β-zearalenone
por: Agahi, Fojan, et al.
Publicado: (2020)

Degradation of Zearalenone by Dielectric Barrier Discharge Cold Plasma and Its Effect on Maize Quality
por: Zheng, Zhe, et al.
Publicado: (2023)

Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
por: Zou, Hui, et al.
Publicado: (2022)

Gap Junction Intercellular Communication Negatively Regulates Cadmium-Induced Autophagy and Inhibition of Autophagic Flux in Buffalo Rat Liver 3A Cells
por: Zou, Hui, et al.
Publicado: (2020)

The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone
por: Wang, Bing-jie, et al.
Publicado: (2018)

Protective Effects of α-Lipoic Acid and Chlorogenic Acid on Cadmium-Induced Liver Injury in Three-Yellow Chickens
por: Shi, Jiabin, et al.
Publicado: (2021)

Puerarin Attenuates Cadmium-Induced Neuronal Injury via Stimulating Cadmium Excretion, Inhibiting Oxidative Stress and Apoptosis
por: Wen, Shuangquan, et al.
Publicado: (2021)

Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway
por: Yuan, Junzhao, et al.
Publicado: (2022)

Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
por: Nagl, Veronika, et al.
Publicado: (2021)

Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size
por: Zou, Hui, et al.
Publicado: (2023)

Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress
por: Sun, Jian, et al.
Publicado: (2023)

Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine
por: IEKO, Takahiro, et al.
Publicado: (2019)

Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes
por: Shi, Jiabin, et al.
Publicado: (2022)

Isolation and Characterization of Lactobacillus paracasei 85 and Lactobacillus buchneri 93 to Absorb and Biotransform Zearalenone
por: Gan, Min, et al.
Publicado: (2022)

Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis
por: Cheng, Yibin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r4mvnkuat20qaft5g0puoifbj7