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Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder
We have previously identified five candidate proteins (matrix metallopeptidase 9 (MMP9), phenylalanyl-TRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin Type 9 (PCSK9)) as potential biomarkers for bipolar II disorder...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703913/ https://www.ncbi.nlm.nih.gov/pubmed/34945756 http://dx.doi.org/10.3390/jpm11121282 |
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author | Lee, Sheng-Yu Wang, Tzu-Yun Lu, Ru-Band Wang, Liang-Jen Chang, Cheng-Ho Chiang, Yung-Chih Pan, Chih-Chuan Tsai, Kuo-Wang |
author_facet | Lee, Sheng-Yu Wang, Tzu-Yun Lu, Ru-Band Wang, Liang-Jen Chang, Cheng-Ho Chiang, Yung-Chih Pan, Chih-Chuan Tsai, Kuo-Wang |
author_sort | Lee, Sheng-Yu |
collection | PubMed |
description | We have previously identified five candidate proteins (matrix metallopeptidase 9 (MMP9), phenylalanyl-TRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin Type 9 (PCSK9)) as potential biomarkers for bipolar II disorder (BD-II). These candidate proteins have been associated with neuroprotective factors (BDNF) and inflammatory factors (cytokines, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α)). However, the correlations between these proteins with plasma BDNF and inflammatory factors remain unknown. We recruited a total of 185 patients with BD-II and 186 healthy controls. Plasma levels of candidate proteins, BDNF, cytokines (TNF-α, CRP, and interleukin-8 (IL-8)) were assessed from each participant. The correlations between levels of candidate proteins, BDNF, and cytokines were analyzed. In the BD-II group, we found that the level of FARSB was positively correlated with the BDNF level (r = 0.397, p < 0.001) and IL-8 (r = 0.320, p < 0.001). The CA-1 level positively correlated with IL-8 (r = 0.318, p < 0.001). In the control group, we found that the FARSB level positively correlated with the BDNF level (r = 0.648, p < 0.001). The CA-1 level positively correlated with TNF-α (r = 0.231, p = 0.002), while the MMP-9 level positively correlated with the CRP level (r = 0.227, p = 0.002). Our results may help in clarifying the underlying mechanism of these candidate proteins for BD-II. |
format | Online Article Text |
id | pubmed-8703913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87039132021-12-25 Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder Lee, Sheng-Yu Wang, Tzu-Yun Lu, Ru-Band Wang, Liang-Jen Chang, Cheng-Ho Chiang, Yung-Chih Pan, Chih-Chuan Tsai, Kuo-Wang J Pers Med Article We have previously identified five candidate proteins (matrix metallopeptidase 9 (MMP9), phenylalanyl-TRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin Type 9 (PCSK9)) as potential biomarkers for bipolar II disorder (BD-II). These candidate proteins have been associated with neuroprotective factors (BDNF) and inflammatory factors (cytokines, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α)). However, the correlations between these proteins with plasma BDNF and inflammatory factors remain unknown. We recruited a total of 185 patients with BD-II and 186 healthy controls. Plasma levels of candidate proteins, BDNF, cytokines (TNF-α, CRP, and interleukin-8 (IL-8)) were assessed from each participant. The correlations between levels of candidate proteins, BDNF, and cytokines were analyzed. In the BD-II group, we found that the level of FARSB was positively correlated with the BDNF level (r = 0.397, p < 0.001) and IL-8 (r = 0.320, p < 0.001). The CA-1 level positively correlated with IL-8 (r = 0.318, p < 0.001). In the control group, we found that the FARSB level positively correlated with the BDNF level (r = 0.648, p < 0.001). The CA-1 level positively correlated with TNF-α (r = 0.231, p = 0.002), while the MMP-9 level positively correlated with the CRP level (r = 0.227, p = 0.002). Our results may help in clarifying the underlying mechanism of these candidate proteins for BD-II. MDPI 2021-12-02 /pmc/articles/PMC8703913/ /pubmed/34945756 http://dx.doi.org/10.3390/jpm11121282 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Sheng-Yu Wang, Tzu-Yun Lu, Ru-Band Wang, Liang-Jen Chang, Cheng-Ho Chiang, Yung-Chih Pan, Chih-Chuan Tsai, Kuo-Wang Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title | Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title_full | Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title_fullStr | Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title_full_unstemmed | Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title_short | Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder |
title_sort | plasma bdnf and cytokines correlated with protein biomarkers for bipolar ii disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703913/ https://www.ncbi.nlm.nih.gov/pubmed/34945756 http://dx.doi.org/10.3390/jpm11121282 |
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