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Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort

Laser balloon (LB) has emerged as an interesting strategy for pulmonary vein isolation in paroxysmal atrial fibrillation (AF). A third-generation LB has recently been developed, allowing a continuous ablation set. We aimed to compare the results from our center’s experience with second and third-gen...

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Autores principales: Guenancia, Charles, Hammache, Nefissa, Docq, Clémence, Benali, Karim, Hooks, Darren, Echivard, Mathieu, Pace, Nathalie, Magnin-Poull, Isabelle, de Chillou, Christian, Sellal, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704020/
https://www.ncbi.nlm.nih.gov/pubmed/34940538
http://dx.doi.org/10.3390/jcdd8120183
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author Guenancia, Charles
Hammache, Nefissa
Docq, Clémence
Benali, Karim
Hooks, Darren
Echivard, Mathieu
Pace, Nathalie
Magnin-Poull, Isabelle
de Chillou, Christian
Sellal, Jean-Marc
author_facet Guenancia, Charles
Hammache, Nefissa
Docq, Clémence
Benali, Karim
Hooks, Darren
Echivard, Mathieu
Pace, Nathalie
Magnin-Poull, Isabelle
de Chillou, Christian
Sellal, Jean-Marc
author_sort Guenancia, Charles
collection PubMed
description Laser balloon (LB) has emerged as an interesting strategy for pulmonary vein isolation in paroxysmal atrial fibrillation (AF). A third-generation LB has recently been developed, allowing a continuous ablation set. We aimed to compare the results from our center’s experience with second and third-generation LBs to a cohort of matched patients who had undergone radiofrequency ablation (RFA) with contact-force catheters. This retrospective monocenter case-control study included our first 50 LB paroxysmal AF ablations (26 second and 24 third-generation LB) and 50 RFA controls, matched on age, sex and left atrial dilation. The two groups had similar baseline parameters. LB procedures were significantly shorter than RFA (129 (110–160) vs. 160 (119–198) min, p = 0.007). During AF ablation, two major complications occurred in each group. At the one-year follow-up, AF recurrence was diagnosed in 7 (14%) of the LB group vs. 14 (28%) of the RFA group (p = 0.14). Moreover, we observed that third-generation LB procedures were associated with shorter laser applications (22 (19–29) vs. 69 (55–76) min, p < 0.001) and procedural durations (111 (100–128) vs. 151.5 (128.5–167) min, p < 0.001) compared to second-generation LB procedures. In the context of the major increase in the number of AF ablations, LB demonstrated consistent results in terms of clinical success, complications and also reduced procedure durations compared to RFA.
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spelling pubmed-87040202021-12-25 Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort Guenancia, Charles Hammache, Nefissa Docq, Clémence Benali, Karim Hooks, Darren Echivard, Mathieu Pace, Nathalie Magnin-Poull, Isabelle de Chillou, Christian Sellal, Jean-Marc J Cardiovasc Dev Dis Article Laser balloon (LB) has emerged as an interesting strategy for pulmonary vein isolation in paroxysmal atrial fibrillation (AF). A third-generation LB has recently been developed, allowing a continuous ablation set. We aimed to compare the results from our center’s experience with second and third-generation LBs to a cohort of matched patients who had undergone radiofrequency ablation (RFA) with contact-force catheters. This retrospective monocenter case-control study included our first 50 LB paroxysmal AF ablations (26 second and 24 third-generation LB) and 50 RFA controls, matched on age, sex and left atrial dilation. The two groups had similar baseline parameters. LB procedures were significantly shorter than RFA (129 (110–160) vs. 160 (119–198) min, p = 0.007). During AF ablation, two major complications occurred in each group. At the one-year follow-up, AF recurrence was diagnosed in 7 (14%) of the LB group vs. 14 (28%) of the RFA group (p = 0.14). Moreover, we observed that third-generation LB procedures were associated with shorter laser applications (22 (19–29) vs. 69 (55–76) min, p < 0.001) and procedural durations (111 (100–128) vs. 151.5 (128.5–167) min, p < 0.001) compared to second-generation LB procedures. In the context of the major increase in the number of AF ablations, LB demonstrated consistent results in terms of clinical success, complications and also reduced procedure durations compared to RFA. MDPI 2021-12-13 /pmc/articles/PMC8704020/ /pubmed/34940538 http://dx.doi.org/10.3390/jcdd8120183 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guenancia, Charles
Hammache, Nefissa
Docq, Clémence
Benali, Karim
Hooks, Darren
Echivard, Mathieu
Pace, Nathalie
Magnin-Poull, Isabelle
de Chillou, Christian
Sellal, Jean-Marc
Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title_full Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title_fullStr Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title_full_unstemmed Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title_short Efficacy and Safety of Second and Third-Generation Laser Balloon for Paroxysmal Atrial Fibrillation Ablation Compared to Radiofrequency Ablation: A Matched-Cohort
title_sort efficacy and safety of second and third-generation laser balloon for paroxysmal atrial fibrillation ablation compared to radiofrequency ablation: a matched-cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704020/
https://www.ncbi.nlm.nih.gov/pubmed/34940538
http://dx.doi.org/10.3390/jcdd8120183
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