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The Interplay of Electrostatics and Chemical Positioning in the Evolution of Antibiotic Resistance in TEM β-Lactamases

[Image: see text] The interplay of enzyme active site electrostatics and chemical positioning is important for understanding the origin(s) of enzyme catalysis and the design of novel catalysts. We reconstruct the evolutionary trajectory of TEM-1 β-lactamase to TEM-52 toward extended-spectrum activit...

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Detalles Bibliográficos
Autores principales:	Schneider, Samuel H., Kozuch, Jacek, Boxer, Steven G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704030/ https://www.ncbi.nlm.nih.gov/pubmed/34963893 http://dx.doi.org/10.1021/acscentsci.1c00880

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