Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

[Image: see text] Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to develop a short and sustainable synthesis from simple raw materials that would min...

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Detalles Bibliográficos
Autores principales: McIntosh, John A., Benkovics, Tamas, Silverman, Steven M., Huffman, Mark A., Kong, Jongrock, Maligres, Peter E., Itoh, Tetsuji, Yang, Hao, Verma, Deeptak, Pan, Weilan, Ho, Hsing-I, Vroom, Jonathan, Knight, Anders M., Hurtak, Jessica A., Klapars, Artis, Fryszkowska, Anna, Morris, William J., Strotman, Neil A., Murphy, Grant S., Maloney, Kevin M., Fier, Patrick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704035/
https://www.ncbi.nlm.nih.gov/pubmed/34963891
http://dx.doi.org/10.1021/acscentsci.1c00608

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