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Lipid specificity of the immune effector perforin

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively cha...

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Detalles Bibliográficos
Autores principales: Hodel, Adrian W., Rudd-Schmidt, Jesse A., Trapani, Joseph A., Voskoboinik, Ilia, Hoogenboom, Bart W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704153/
https://www.ncbi.nlm.nih.gov/pubmed/34545865
http://dx.doi.org/10.1039/d0fd00043d