Cargando…

Lipid specificity of the immune effector perforin

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hodel, Adrian W., Rudd-Schmidt, Jesse A., Trapani, Joseph A., Voskoboinik, Ilia, Hoogenboom, Bart W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704153/ https://www.ncbi.nlm.nih.gov/pubmed/34545865 http://dx.doi.org/10.1039/d0fd00043d

Ejemplares similares

Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function
por: Voskoboinik, Ilia, et al.
Publicado: (2013)

Lipid order and charge protect killer T cells from accidental death
por: Rudd-Schmidt, Jesse A., et al.
Publicado: (2019)

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse
por: Rudd-Schmidt, Jesse A., et al.
Publicado: (2022)

The pore conformation of lymphocyte perforin
por: Ivanova, Marina E., et al.
Publicado: (2022)

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity
por: Spicer, Julie A., et al.
Publicado: (2022)

Human perforin mutations and susceptibility to multiple primary cancers
por: Trapani, Joseph A., et al.
Publicado: (2013)

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin
por: Spicer, Julie A., et al.
Publicado: (2013)

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene
por: Voskoboinik, Ilia, et al.
Publicado: (2004)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
por: Pang, Siew Siew, et al.
Publicado: (2019)

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
por: Lukoyanova, Natalya, et al.
Publicado: (2015)

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time
por: Jenkins, Misty R., et al.
Publicado: (2015)

Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
por: Bayly-Jones, Charles, et al.
Publicado: (2020)

Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017)

Diarylthiophenes as inhibitors of the pore-forming protein perforin
por: Miller, Christian K., et al.
Publicado: (2016)

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma
por: Smyth, Mark J., et al.
Publicado: (2000)

Molecular study of the perforin gene in familial hematological malignancies
por: El Abed, Rim, et al.
Publicado: (2011)

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis
por: Spicer, Julie A., et al.
Publicado: (2017)

Perforin Gene Transfer Into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency
por: Carmo, Marlene, et al.
Publicado: (2015)

Perforin: an important player in immune response
por: Osińska, Iwona, et al.
Publicado: (2014)

Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner
por: Wijesundara, Danushka K., et al.
Publicado: (2017)

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
por: Rodríguez-Silvestre, Pablo, et al.
Publicado: (2023)

NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer
por: Smyth, Mark J., et al.
Publicado: (2004)

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD
por: Wang, Qian, et al.
Publicado: (2020)

Editorial: Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis
por: Munson, George P., et al.
Publicado: (2022)

Perforin and hematological cancer
por: Covas, Dimas Tadeu
Publicado: (2011)

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization
por: Shi, Lianfa, et al.
Publicado: (1997)

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
por: Welz, M., et al.
Publicado: (2018)

Determination of quantitative and site-specific DNA methylation of perforin by pyrosequencing
por: Narasimhan, Supraja, et al.
Publicado: (2009)

Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis
por: Sutton, Vivien R., et al.
Publicado: (2007)

The major CD8 T cell effector memory subset in the normal and Chlamydia trachomatis-infected human endocervix is low in perforin
por: Ibana, Joyce A, et al.
Publicado: (2012)

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi
por: D’Angelo, Michael E, et al.
Publicado: (2012)

Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
por: Gartlan, Kate H., et al.
Publicado: (2022)

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes
por: Tadokoro, Hiroko, et al.
Publicado: (2020)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer
por: Chuang, C-H, et al.
Publicado: (2014)

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis
por: Hagn, Magdalena, et al.
Publicado: (2015)

Physical modelling of the nuclear pore complex
por: Osmanović, Dino, et al.
Publicado: (2013)

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
por: Waterhouse, Nigel J., et al.
Publicado: (2006)

Dilemmas in the diagnosis and pathogenesis of atypical late‐onset familial haemophagocytic lymphohistiocytosis
por: Minson, Adrian, et al.
Publicado: (2021)

Perforin-Like Proteins of Apicomplexan Parasites
por: Sassmannshausen, Juliane, et al.
Publicado: (2020)

Perforin and resistance to SARS coronavirus 2
por: Cunningham, Louise, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qu7sh62jbbv29fo3n30ijb11md