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Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer
Surgery and radiation therapy are both commonly used in the treatment of early stage (AJCC stages T1-T2 N0-M0) oropharyngeal squamous cell carcinoma (OPSCC). Transoral robotic surgery (TORS) and intensity modulated radiation therapy (IMRT) have been reported to result in similar survival and disease...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704187/ https://www.ncbi.nlm.nih.gov/pubmed/34936505 http://dx.doi.org/10.1177/10732748211050770 |
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author | Hilal, Lara Moukarbel, Roger Ollaik, Farah Yang, Pei Youssef, Bassem |
author_facet | Hilal, Lara Moukarbel, Roger Ollaik, Farah Yang, Pei Youssef, Bassem |
author_sort | Hilal, Lara |
collection | PubMed |
description | Surgery and radiation therapy are both commonly used in the treatment of early stage (AJCC stages T1-T2 N0-M0) oropharyngeal squamous cell carcinoma (OPSCC). Transoral robotic surgery (TORS) and intensity modulated radiation therapy (IMRT) have been reported to result in similar survival and disease control outcomes. However, their side effect profiles widely differ. Nevertheless, patients who experience the worst side effects and quality of life are the ones who receive the combination of TORS and adjuvant radiation or chemoradiation therapy. Thus, appropriate patient selection for surgery to minimize the need for multimodality therapy is key. We propose, in this paper, the use of sentinel lymph node biopsy in the node negative (N0) neck as a means that is worth exploring for selecting patients to either radiation therapy or surgery. Patients with a positive sentinel lymph node (SLN) would be better directed to upfront radiation. On the contrary, patients with a negative SLN biopsy would be more confidently directed towards TORS and neck dissection alone. |
format | Online Article Text |
id | pubmed-8704187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87041872021-12-25 Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer Hilal, Lara Moukarbel, Roger Ollaik, Farah Yang, Pei Youssef, Bassem Cancer Control Perspective Surgery and radiation therapy are both commonly used in the treatment of early stage (AJCC stages T1-T2 N0-M0) oropharyngeal squamous cell carcinoma (OPSCC). Transoral robotic surgery (TORS) and intensity modulated radiation therapy (IMRT) have been reported to result in similar survival and disease control outcomes. However, their side effect profiles widely differ. Nevertheless, patients who experience the worst side effects and quality of life are the ones who receive the combination of TORS and adjuvant radiation or chemoradiation therapy. Thus, appropriate patient selection for surgery to minimize the need for multimodality therapy is key. We propose, in this paper, the use of sentinel lymph node biopsy in the node negative (N0) neck as a means that is worth exploring for selecting patients to either radiation therapy or surgery. Patients with a positive sentinel lymph node (SLN) would be better directed to upfront radiation. On the contrary, patients with a negative SLN biopsy would be more confidently directed towards TORS and neck dissection alone. SAGE Publications 2021-12-22 /pmc/articles/PMC8704187/ /pubmed/34936505 http://dx.doi.org/10.1177/10732748211050770 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Perspective Hilal, Lara Moukarbel, Roger Ollaik, Farah Yang, Pei Youssef, Bassem Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title | Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title_full | Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title_fullStr | Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title_full_unstemmed | Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title_short | Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer |
title_sort | patient selection for surgery vs radiotherapy for early stage oropharyngeal cancer |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704187/ https://www.ncbi.nlm.nih.gov/pubmed/34936505 http://dx.doi.org/10.1177/10732748211050770 |
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