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Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers

[Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike mo...

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Autores principales: Xiong, Yan, Lin, Zhiwei, Mostarac, Deniz, Minevich, Brian, Peng, Qiuyuan, Zhu, Guolong, Sánchez, Pedro A., Kantorovich, Sofia, Ke, Yonggang, Gang, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704199/
https://www.ncbi.nlm.nih.gov/pubmed/34647751
http://dx.doi.org/10.1021/acs.nanolett.1c03009
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author Xiong, Yan
Lin, Zhiwei
Mostarac, Deniz
Minevich, Brian
Peng, Qiuyuan
Zhu, Guolong
Sánchez, Pedro A.
Kantorovich, Sofia
Ke, Yonggang
Gang, Oleg
author_facet Xiong, Yan
Lin, Zhiwei
Mostarac, Deniz
Minevich, Brian
Peng, Qiuyuan
Zhu, Guolong
Sánchez, Pedro A.
Kantorovich, Sofia
Ke, Yonggang
Gang, Oleg
author_sort Xiong, Yan
collection PubMed
description [Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike molecular systems where valence bonds can be envisioned as pointlike interactions nanoscale patches are often realized through multiple molecular linkages. The relationship between the characteristics of these linkages, the resulting interpatch connectivity, and assembly morphology is not well-explored. Here, we investigate assembly behavior of model divalent nanomonomers, DNA nanocuboid with tailorable multilinking bonds. Our study reveals that the characteristics of individual molecular linkages and their collective properties have a profound effect on nanomonomer reactivity and resulting morphologies. Beyond linear nanopolymers, a common signature of divalent nanomonomers, we observe an effective valence increase as linkages lengthened, leading to the nanopolymer bundling. The experimental findings are rationalized by molecular dynamics simulations.
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spelling pubmed-87041992021-12-27 Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers Xiong, Yan Lin, Zhiwei Mostarac, Deniz Minevich, Brian Peng, Qiuyuan Zhu, Guolong Sánchez, Pedro A. Kantorovich, Sofia Ke, Yonggang Gang, Oleg Nano Lett [Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike molecular systems where valence bonds can be envisioned as pointlike interactions nanoscale patches are often realized through multiple molecular linkages. The relationship between the characteristics of these linkages, the resulting interpatch connectivity, and assembly morphology is not well-explored. Here, we investigate assembly behavior of model divalent nanomonomers, DNA nanocuboid with tailorable multilinking bonds. Our study reveals that the characteristics of individual molecular linkages and their collective properties have a profound effect on nanomonomer reactivity and resulting morphologies. Beyond linear nanopolymers, a common signature of divalent nanomonomers, we observe an effective valence increase as linkages lengthened, leading to the nanopolymer bundling. The experimental findings are rationalized by molecular dynamics simulations. American Chemical Society 2021-10-14 2021-12-22 /pmc/articles/PMC8704199/ /pubmed/34647751 http://dx.doi.org/10.1021/acs.nanolett.1c03009 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Xiong, Yan
Lin, Zhiwei
Mostarac, Deniz
Minevich, Brian
Peng, Qiuyuan
Zhu, Guolong
Sánchez, Pedro A.
Kantorovich, Sofia
Ke, Yonggang
Gang, Oleg
Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title_full Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title_fullStr Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title_full_unstemmed Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title_short Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
title_sort divalent multilinking bonds control growth and morphology of nanopolymers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704199/
https://www.ncbi.nlm.nih.gov/pubmed/34647751
http://dx.doi.org/10.1021/acs.nanolett.1c03009
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