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Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers
[Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike mo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704199/ https://www.ncbi.nlm.nih.gov/pubmed/34647751 http://dx.doi.org/10.1021/acs.nanolett.1c03009 |
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author | Xiong, Yan Lin, Zhiwei Mostarac, Deniz Minevich, Brian Peng, Qiuyuan Zhu, Guolong Sánchez, Pedro A. Kantorovich, Sofia Ke, Yonggang Gang, Oleg |
author_facet | Xiong, Yan Lin, Zhiwei Mostarac, Deniz Minevich, Brian Peng, Qiuyuan Zhu, Guolong Sánchez, Pedro A. Kantorovich, Sofia Ke, Yonggang Gang, Oleg |
author_sort | Xiong, Yan |
collection | PubMed |
description | [Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike molecular systems where valence bonds can be envisioned as pointlike interactions nanoscale patches are often realized through multiple molecular linkages. The relationship between the characteristics of these linkages, the resulting interpatch connectivity, and assembly morphology is not well-explored. Here, we investigate assembly behavior of model divalent nanomonomers, DNA nanocuboid with tailorable multilinking bonds. Our study reveals that the characteristics of individual molecular linkages and their collective properties have a profound effect on nanomonomer reactivity and resulting morphologies. Beyond linear nanopolymers, a common signature of divalent nanomonomers, we observe an effective valence increase as linkages lengthened, leading to the nanopolymer bundling. The experimental findings are rationalized by molecular dynamics simulations. |
format | Online Article Text |
id | pubmed-8704199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87041992021-12-27 Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers Xiong, Yan Lin, Zhiwei Mostarac, Deniz Minevich, Brian Peng, Qiuyuan Zhu, Guolong Sánchez, Pedro A. Kantorovich, Sofia Ke, Yonggang Gang, Oleg Nano Lett [Image: see text] Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike molecular systems where valence bonds can be envisioned as pointlike interactions nanoscale patches are often realized through multiple molecular linkages. The relationship between the characteristics of these linkages, the resulting interpatch connectivity, and assembly morphology is not well-explored. Here, we investigate assembly behavior of model divalent nanomonomers, DNA nanocuboid with tailorable multilinking bonds. Our study reveals that the characteristics of individual molecular linkages and their collective properties have a profound effect on nanomonomer reactivity and resulting morphologies. Beyond linear nanopolymers, a common signature of divalent nanomonomers, we observe an effective valence increase as linkages lengthened, leading to the nanopolymer bundling. The experimental findings are rationalized by molecular dynamics simulations. American Chemical Society 2021-10-14 2021-12-22 /pmc/articles/PMC8704199/ /pubmed/34647751 http://dx.doi.org/10.1021/acs.nanolett.1c03009 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Xiong, Yan Lin, Zhiwei Mostarac, Deniz Minevich, Brian Peng, Qiuyuan Zhu, Guolong Sánchez, Pedro A. Kantorovich, Sofia Ke, Yonggang Gang, Oleg Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers |
title | Divalent Multilinking Bonds Control Growth and Morphology
of Nanopolymers |
title_full | Divalent Multilinking Bonds Control Growth and Morphology
of Nanopolymers |
title_fullStr | Divalent Multilinking Bonds Control Growth and Morphology
of Nanopolymers |
title_full_unstemmed | Divalent Multilinking Bonds Control Growth and Morphology
of Nanopolymers |
title_short | Divalent Multilinking Bonds Control Growth and Morphology
of Nanopolymers |
title_sort | divalent multilinking bonds control growth and morphology
of nanopolymers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704199/ https://www.ncbi.nlm.nih.gov/pubmed/34647751 http://dx.doi.org/10.1021/acs.nanolett.1c03009 |
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