KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?

In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Koistinen, Hannu, Künnapuu, Jaana, Jeltsch, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704207/
https://www.ncbi.nlm.nih.gov/pubmed/34948344
http://dx.doi.org/10.3390/ijms222413545
_version_ 1784621651527204864
author Koistinen, Hannu
Künnapuu, Jaana
Jeltsch, Michael
author_facet Koistinen, Hannu
Künnapuu, Jaana
Jeltsch, Michael
author_sort Koistinen, Hannu
collection PubMed
description In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activity. However, more recent evidence suggests that KLK3 may also have an opposite role, mediated by the ability of KLK3 to activate the (lymph)angiogenic vascular endothelial growth factors VEGF-C and VEGF-D, further discussed in the review.
format Online
Article
Text
id pubmed-8704207
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87042072021-12-25 KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not? Koistinen, Hannu Künnapuu, Jaana Jeltsch, Michael Int J Mol Sci Review In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activity. However, more recent evidence suggests that KLK3 may also have an opposite role, mediated by the ability of KLK3 to activate the (lymph)angiogenic vascular endothelial growth factors VEGF-C and VEGF-D, further discussed in the review. MDPI 2021-12-17 /pmc/articles/PMC8704207/ /pubmed/34948344 http://dx.doi.org/10.3390/ijms222413545 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koistinen, Hannu
Künnapuu, Jaana
Jeltsch, Michael
KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title_full KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title_fullStr KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title_full_unstemmed KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title_short KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?
title_sort klk3 in the regulation of angiogenesis—tumorigenic or not?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704207/
https://www.ncbi.nlm.nih.gov/pubmed/34948344
http://dx.doi.org/10.3390/ijms222413545
work_keys_str_mv AT koistinenhannu klk3intheregulationofangiogenesistumorigenicornot
AT kunnapuujaana klk3intheregulationofangiogenesistumorigenicornot
AT jeltschmichael klk3intheregulationofangiogenesistumorigenicornot

Ejemplares similares