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Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds
The anti-inflammatory and antihyperglycemic effects of polysaccharides extracted from Alhagi maurorum Medik. seeds, spontaneous shrub collected in Southern of Algerian Sahara were investigated. Their water extraction followed by alcoholic precipitation was conducted to obtain two water-soluble polys...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704266/ https://www.ncbi.nlm.nih.gov/pubmed/34961129 http://dx.doi.org/10.3390/plants10122658 |
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| author | Chakou, Fatma Zohra Boual, Zakaria Hadj, Mohamed Didi Ould El Belkhalfa, Hakim Bachari, Khaldoun El Alaoui-Talibi, Zainab El Modafar, Cherkaoui Hadjkacem, Farah Fendri, Imen Abdelkafi, Slim Traïkia, Mounir Cerf, Didier Le Dubessay, Pascal Delattre, Cédric Pierre, Guillaume Michaud, Philippe |
| author_facet | Chakou, Fatma Zohra Boual, Zakaria Hadj, Mohamed Didi Ould El Belkhalfa, Hakim Bachari, Khaldoun El Alaoui-Talibi, Zainab El Modafar, Cherkaoui Hadjkacem, Farah Fendri, Imen Abdelkafi, Slim Traïkia, Mounir Cerf, Didier Le Dubessay, Pascal Delattre, Cédric Pierre, Guillaume Michaud, Philippe |
| author_sort | Chakou, Fatma Zohra |
| collection | PubMed |
| description | The anti-inflammatory and antihyperglycemic effects of polysaccharides extracted from Alhagi maurorum Medik. seeds, spontaneous shrub collected in Southern of Algerian Sahara were investigated. Their water extraction followed by alcoholic precipitation was conducted to obtain two water-soluble polysaccharides extracts (WSPAM1 and WSPAM2). They were characterized using Fourier transform infrared, (1)H/(13)C Nuclear Magnetic Resonance, Gas Chromatography-Mass Spectrometry and Size Exclusion Chromatography coupled with Multi-Angle Light Scattering. The capacity of those fractions to inhibit α-amylase activity and thermally induced Bovine Serum Albumin denaturation were also investigated. WSPAM1 and WSPAM2 were galactomannans with a mannose/galactose ratio of 2.2 and 2.4, respectively. The SEC-MALLS analysis revealed that WSPAM1 had a molecular weight of 1.4 × 10(6) Da. The investigations highlighted antinflammatory and antihyperglycemic effects in a dose-dependant manner of WSPAM1 and WSPAM2. |
| format | Online Article Text |
| id | pubmed-8704266 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87042662021-12-25 Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds Chakou, Fatma Zohra Boual, Zakaria Hadj, Mohamed Didi Ould El Belkhalfa, Hakim Bachari, Khaldoun El Alaoui-Talibi, Zainab El Modafar, Cherkaoui Hadjkacem, Farah Fendri, Imen Abdelkafi, Slim Traïkia, Mounir Cerf, Didier Le Dubessay, Pascal Delattre, Cédric Pierre, Guillaume Michaud, Philippe Plants (Basel) Article The anti-inflammatory and antihyperglycemic effects of polysaccharides extracted from Alhagi maurorum Medik. seeds, spontaneous shrub collected in Southern of Algerian Sahara were investigated. Their water extraction followed by alcoholic precipitation was conducted to obtain two water-soluble polysaccharides extracts (WSPAM1 and WSPAM2). They were characterized using Fourier transform infrared, (1)H/(13)C Nuclear Magnetic Resonance, Gas Chromatography-Mass Spectrometry and Size Exclusion Chromatography coupled with Multi-Angle Light Scattering. The capacity of those fractions to inhibit α-amylase activity and thermally induced Bovine Serum Albumin denaturation were also investigated. WSPAM1 and WSPAM2 were galactomannans with a mannose/galactose ratio of 2.2 and 2.4, respectively. The SEC-MALLS analysis revealed that WSPAM1 had a molecular weight of 1.4 × 10(6) Da. The investigations highlighted antinflammatory and antihyperglycemic effects in a dose-dependant manner of WSPAM1 and WSPAM2. MDPI 2021-12-03 /pmc/articles/PMC8704266/ /pubmed/34961129 http://dx.doi.org/10.3390/plants10122658 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Chakou, Fatma Zohra Boual, Zakaria Hadj, Mohamed Didi Ould El Belkhalfa, Hakim Bachari, Khaldoun El Alaoui-Talibi, Zainab El Modafar, Cherkaoui Hadjkacem, Farah Fendri, Imen Abdelkafi, Slim Traïkia, Mounir Cerf, Didier Le Dubessay, Pascal Delattre, Cédric Pierre, Guillaume Michaud, Philippe Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title | Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title_full | Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title_fullStr | Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title_full_unstemmed | Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title_short | Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds |
| title_sort | pharmacological investigations in traditional utilization of alhagi maurorum medik. in saharan algeria: in vitro study of anti-inflammatory and antihyperglycemic activities of water-soluble polysaccharides extracted from the seeds |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704266/ https://www.ncbi.nlm.nih.gov/pubmed/34961129 http://dx.doi.org/10.3390/plants10122658 |
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