Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural kill...

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Autores principales: Miao, Yan-Dong, Wang, Jiang-Tao, Tang, Xiao-Long, Mi, Deng-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704271/
https://www.ncbi.nlm.nih.gov/pubmed/35068863
http://dx.doi.org/10.3748/wjg.v27.i47.8194
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author Miao, Yan-Dong
Wang, Jiang-Tao
Tang, Xiao-Long
Mi, Deng-Hai
author_facet Miao, Yan-Dong
Wang, Jiang-Tao
Tang, Xiao-Long
Mi, Deng-Hai
author_sort Miao, Yan-Dong
collection PubMed
description CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, P < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.
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spelling pubmed-87042712022-01-20 Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model Miao, Yan-Dong Wang, Jiang-Tao Tang, Xiao-Long Mi, Deng-Hai World J Gastroenterol Letter to the Editor CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, P < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway. Baishideng Publishing Group Inc 2021-12-21 2021-12-21 /pmc/articles/PMC8704271/ /pubmed/35068863 http://dx.doi.org/10.3748/wjg.v27.i47.8194 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Letter to the Editor
Miao, Yan-Dong
Wang, Jiang-Tao
Tang, Xiao-Long
Mi, Deng-Hai
Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title_full Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title_fullStr Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title_full_unstemmed Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title_short Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
title_sort microarray analysis to explore the effect of cxcl12 isoforms in a pancreatic pre-tumor cell model
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704271/
https://www.ncbi.nlm.nih.gov/pubmed/35068863
http://dx.doi.org/10.3748/wjg.v27.i47.8194
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