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Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation

Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a...

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Autores principales: Mooranian, Armin, Jones, Melissa, Ionescu, Corina Mihaela, Walker, Daniel, Wagle, Susbin Raj, Kovacevic, Bozica, Chester, Jacqueline, Foster, Thomas, Johnston, Edan, Kuthubutheen, Jafri, Brown, Daniel, Mikov, Momir, Al-Salami, Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704355/
https://www.ncbi.nlm.nih.gov/pubmed/34940547
http://dx.doi.org/10.3390/jfb12040068
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author Mooranian, Armin
Jones, Melissa
Ionescu, Corina Mihaela
Walker, Daniel
Wagle, Susbin Raj
Kovacevic, Bozica
Chester, Jacqueline
Foster, Thomas
Johnston, Edan
Kuthubutheen, Jafri
Brown, Daniel
Mikov, Momir
Al-Salami, Hani
author_facet Mooranian, Armin
Jones, Melissa
Ionescu, Corina Mihaela
Walker, Daniel
Wagle, Susbin Raj
Kovacevic, Bozica
Chester, Jacqueline
Foster, Thomas
Johnston, Edan
Kuthubutheen, Jafri
Brown, Daniel
Mikov, Momir
Al-Salami, Hani
author_sort Mooranian, Armin
collection PubMed
description Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a potential cure is the immunoisolation of β cells via artificial cell microencapsulation (ACM), with ongoing promising results in human and animal studies that do not depend on immunosuppressive regimens. However, significant challenges remain in the formulation and delivery platforms and potential immunogenicity issues. Additionally, the level of impact on key metabolic and disease biomarkers and long-term benefits from human and animal studies stemming from the encapsulation and delivery of these cells is a subject of continuing debate. The purpose of this review is to summarise key advances in this field of islet transplantation using ACM and to explore future strategies, limitations, and hurdles as well as upcoming developments utilising bioengineering and current clinical trials.
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spelling pubmed-87043552021-12-25 Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation Mooranian, Armin Jones, Melissa Ionescu, Corina Mihaela Walker, Daniel Wagle, Susbin Raj Kovacevic, Bozica Chester, Jacqueline Foster, Thomas Johnston, Edan Kuthubutheen, Jafri Brown, Daniel Mikov, Momir Al-Salami, Hani J Funct Biomater Review Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a potential cure is the immunoisolation of β cells via artificial cell microencapsulation (ACM), with ongoing promising results in human and animal studies that do not depend on immunosuppressive regimens. However, significant challenges remain in the formulation and delivery platforms and potential immunogenicity issues. Additionally, the level of impact on key metabolic and disease biomarkers and long-term benefits from human and animal studies stemming from the encapsulation and delivery of these cells is a subject of continuing debate. The purpose of this review is to summarise key advances in this field of islet transplantation using ACM and to explore future strategies, limitations, and hurdles as well as upcoming developments utilising bioengineering and current clinical trials. MDPI 2021-11-30 /pmc/articles/PMC8704355/ /pubmed/34940547 http://dx.doi.org/10.3390/jfb12040068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mooranian, Armin
Jones, Melissa
Ionescu, Corina Mihaela
Walker, Daniel
Wagle, Susbin Raj
Kovacevic, Bozica
Chester, Jacqueline
Foster, Thomas
Johnston, Edan
Kuthubutheen, Jafri
Brown, Daniel
Mikov, Momir
Al-Salami, Hani
Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title_full Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title_fullStr Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title_full_unstemmed Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title_short Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
title_sort artificial cell encapsulation for biomaterials and tissue bio-nanoengineering: history, achievements, limitations, and future work for potential clinical applications and transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704355/
https://www.ncbi.nlm.nih.gov/pubmed/34940547
http://dx.doi.org/10.3390/jfb12040068
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