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Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704355/ https://www.ncbi.nlm.nih.gov/pubmed/34940547 http://dx.doi.org/10.3390/jfb12040068 |
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author | Mooranian, Armin Jones, Melissa Ionescu, Corina Mihaela Walker, Daniel Wagle, Susbin Raj Kovacevic, Bozica Chester, Jacqueline Foster, Thomas Johnston, Edan Kuthubutheen, Jafri Brown, Daniel Mikov, Momir Al-Salami, Hani |
author_facet | Mooranian, Armin Jones, Melissa Ionescu, Corina Mihaela Walker, Daniel Wagle, Susbin Raj Kovacevic, Bozica Chester, Jacqueline Foster, Thomas Johnston, Edan Kuthubutheen, Jafri Brown, Daniel Mikov, Momir Al-Salami, Hani |
author_sort | Mooranian, Armin |
collection | PubMed |
description | Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a potential cure is the immunoisolation of β cells via artificial cell microencapsulation (ACM), with ongoing promising results in human and animal studies that do not depend on immunosuppressive regimens. However, significant challenges remain in the formulation and delivery platforms and potential immunogenicity issues. Additionally, the level of impact on key metabolic and disease biomarkers and long-term benefits from human and animal studies stemming from the encapsulation and delivery of these cells is a subject of continuing debate. The purpose of this review is to summarise key advances in this field of islet transplantation using ACM and to explore future strategies, limitations, and hurdles as well as upcoming developments utilising bioengineering and current clinical trials. |
format | Online Article Text |
id | pubmed-8704355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87043552021-12-25 Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation Mooranian, Armin Jones, Melissa Ionescu, Corina Mihaela Walker, Daniel Wagle, Susbin Raj Kovacevic, Bozica Chester, Jacqueline Foster, Thomas Johnston, Edan Kuthubutheen, Jafri Brown, Daniel Mikov, Momir Al-Salami, Hani J Funct Biomater Review Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the availability of parental insulin, serious complications of both types are profound and endemic. One approach to therapy and a potential cure is the immunoisolation of β cells via artificial cell microencapsulation (ACM), with ongoing promising results in human and animal studies that do not depend on immunosuppressive regimens. However, significant challenges remain in the formulation and delivery platforms and potential immunogenicity issues. Additionally, the level of impact on key metabolic and disease biomarkers and long-term benefits from human and animal studies stemming from the encapsulation and delivery of these cells is a subject of continuing debate. The purpose of this review is to summarise key advances in this field of islet transplantation using ACM and to explore future strategies, limitations, and hurdles as well as upcoming developments utilising bioengineering and current clinical trials. MDPI 2021-11-30 /pmc/articles/PMC8704355/ /pubmed/34940547 http://dx.doi.org/10.3390/jfb12040068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mooranian, Armin Jones, Melissa Ionescu, Corina Mihaela Walker, Daniel Wagle, Susbin Raj Kovacevic, Bozica Chester, Jacqueline Foster, Thomas Johnston, Edan Kuthubutheen, Jafri Brown, Daniel Mikov, Momir Al-Salami, Hani Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title | Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title_full | Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title_fullStr | Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title_full_unstemmed | Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title_short | Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation |
title_sort | artificial cell encapsulation for biomaterials and tissue bio-nanoengineering: history, achievements, limitations, and future work for potential clinical applications and transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704355/ https://www.ncbi.nlm.nih.gov/pubmed/34940547 http://dx.doi.org/10.3390/jfb12040068 |
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