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DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis

As one of the leading causes of bone fracture in postmenopausal women and in older men, osteoporosis worldwide is attracting more attention in recent decades. Osteoporosis is a common disease mainly resulting from an imbalance of bone formation and bone resorption. Pharmaceutically active compounds...

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Autores principales: Yang, Zhengmeng, Feng, Lu, Wang, Haixing, Li, Yucong, Lo, Jessica Hiu Tung, Zhang, Xiaoting, Lu, Xuan, Wang, Yaofeng, Lin, Sien, Tortorella, Micky D., Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704418/
https://www.ncbi.nlm.nih.gov/pubmed/34960006
http://dx.doi.org/10.3390/nu13124455
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author Yang, Zhengmeng
Feng, Lu
Wang, Haixing
Li, Yucong
Lo, Jessica Hiu Tung
Zhang, Xiaoting
Lu, Xuan
Wang, Yaofeng
Lin, Sien
Tortorella, Micky D.
Li, Gang
author_facet Yang, Zhengmeng
Feng, Lu
Wang, Haixing
Li, Yucong
Lo, Jessica Hiu Tung
Zhang, Xiaoting
Lu, Xuan
Wang, Yaofeng
Lin, Sien
Tortorella, Micky D.
Li, Gang
author_sort Yang, Zhengmeng
collection PubMed
description As one of the leading causes of bone fracture in postmenopausal women and in older men, osteoporosis worldwide is attracting more attention in recent decades. Osteoporosis is a common disease mainly resulting from an imbalance of bone formation and bone resorption. Pharmaceutically active compounds that both activate osteogenesis, while repressing osteoclastogenesis hold the potential of being therapeutic medications for osteoporosis treatment. In the present study, sesamin, a bioactive ingredient derived from the seed of Sesamum Indicum, was screened out from a bioactive compound library and shown to exhibit dual-regulating functions on these two processes. Sesamin was demonstrated to promote osteogenesis by upregulating Wnt/β-catenin, while repressing osteoclastogenesis via downregulating NF-κB signaling . Furthermore, DANCR was found to be the key regulator in sesamin-mediated bone formation and resorption . In an ovariectomy (OVX)-induced osteoporotic mouse model, sesamin could rescue OVX-induced bone loss and impairment. The increased serum level of DANCR caused by OVX was also downregulated upon sesamin treatment. In conclusion, our results demonstrate that sesamin plays a dual-functional role in both osteogenesis activation and osteoclastogenesis de-activation in a DANCR-dependent manner, suggesting that it may be a possible medication candidate for osteoporotic patients with elevated DNACR expression levels.
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spelling pubmed-87044182021-12-25 DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis Yang, Zhengmeng Feng, Lu Wang, Haixing Li, Yucong Lo, Jessica Hiu Tung Zhang, Xiaoting Lu, Xuan Wang, Yaofeng Lin, Sien Tortorella, Micky D. Li, Gang Nutrients Article As one of the leading causes of bone fracture in postmenopausal women and in older men, osteoporosis worldwide is attracting more attention in recent decades. Osteoporosis is a common disease mainly resulting from an imbalance of bone formation and bone resorption. Pharmaceutically active compounds that both activate osteogenesis, while repressing osteoclastogenesis hold the potential of being therapeutic medications for osteoporosis treatment. In the present study, sesamin, a bioactive ingredient derived from the seed of Sesamum Indicum, was screened out from a bioactive compound library and shown to exhibit dual-regulating functions on these two processes. Sesamin was demonstrated to promote osteogenesis by upregulating Wnt/β-catenin, while repressing osteoclastogenesis via downregulating NF-κB signaling . Furthermore, DANCR was found to be the key regulator in sesamin-mediated bone formation and resorption . In an ovariectomy (OVX)-induced osteoporotic mouse model, sesamin could rescue OVX-induced bone loss and impairment. The increased serum level of DANCR caused by OVX was also downregulated upon sesamin treatment. In conclusion, our results demonstrate that sesamin plays a dual-functional role in both osteogenesis activation and osteoclastogenesis de-activation in a DANCR-dependent manner, suggesting that it may be a possible medication candidate for osteoporotic patients with elevated DNACR expression levels. MDPI 2021-12-13 /pmc/articles/PMC8704418/ /pubmed/34960006 http://dx.doi.org/10.3390/nu13124455 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Zhengmeng
Feng, Lu
Wang, Haixing
Li, Yucong
Lo, Jessica Hiu Tung
Zhang, Xiaoting
Lu, Xuan
Wang, Yaofeng
Lin, Sien
Tortorella, Micky D.
Li, Gang
DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title_full DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title_fullStr DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title_full_unstemmed DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title_short DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis
title_sort dancr mediates the rescuing effects of sesamin on postmenopausal osteoporosis treatment via orchestrating osteogenesis and osteoclastogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704418/
https://www.ncbi.nlm.nih.gov/pubmed/34960006
http://dx.doi.org/10.3390/nu13124455
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