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Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique
Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment us...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704422/ https://www.ncbi.nlm.nih.gov/pubmed/34946260 http://dx.doi.org/10.3390/medicina57121315 |
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author | Fukahori, Susumu Obase, Yasushi Fukushima, Chizu Takao, Daisuke Iriki, Jun Ozasa, Mutsumi Zaizen, Yoshiaki Takamura, Noboru Fukuoka, Junya Ashizawa, Kazuto Mukae, Hiroshi |
author_facet | Fukahori, Susumu Obase, Yasushi Fukushima, Chizu Takao, Daisuke Iriki, Jun Ozasa, Mutsumi Zaizen, Yoshiaki Takamura, Noboru Fukuoka, Junya Ashizawa, Kazuto Mukae, Hiroshi |
author_sort | Fukahori, Susumu |
collection | PubMed |
description | Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment using conventional spirometry because the lesions are located in small airways. However, it has been reported that the forced oscillation technique (FOT) is useful in the evaluation of small airway disease in bronchial asthma or chronic obstructive pulmonary disease. We performed the FOT to determine the effect of treatment on bronchocentric granulomatosis and found it to be useful. We report the case of a 55-year-old female with ulcerative colitis who was treated with golimumab and who developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. She was successfully treated with prednisone, and the treatment efficacy was confirmed by the FOT. The FOT may be useful in the evaluation of small airway disease in bronchocentric granulomatosis. This case may help inform clinicians of the usefulness of the FOT to assess small airway disease in various diseases. |
format | Online Article Text |
id | pubmed-8704422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87044222021-12-25 Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique Fukahori, Susumu Obase, Yasushi Fukushima, Chizu Takao, Daisuke Iriki, Jun Ozasa, Mutsumi Zaizen, Yoshiaki Takamura, Noboru Fukuoka, Junya Ashizawa, Kazuto Mukae, Hiroshi Medicina (Kaunas) Case Report Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment using conventional spirometry because the lesions are located in small airways. However, it has been reported that the forced oscillation technique (FOT) is useful in the evaluation of small airway disease in bronchial asthma or chronic obstructive pulmonary disease. We performed the FOT to determine the effect of treatment on bronchocentric granulomatosis and found it to be useful. We report the case of a 55-year-old female with ulcerative colitis who was treated with golimumab and who developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. She was successfully treated with prednisone, and the treatment efficacy was confirmed by the FOT. The FOT may be useful in the evaluation of small airway disease in bronchocentric granulomatosis. This case may help inform clinicians of the usefulness of the FOT to assess small airway disease in various diseases. MDPI 2021-11-30 /pmc/articles/PMC8704422/ /pubmed/34946260 http://dx.doi.org/10.3390/medicina57121315 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Fukahori, Susumu Obase, Yasushi Fukushima, Chizu Takao, Daisuke Iriki, Jun Ozasa, Mutsumi Zaizen, Yoshiaki Takamura, Noboru Fukuoka, Junya Ashizawa, Kazuto Mukae, Hiroshi Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title | Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title_full | Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title_fullStr | Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title_full_unstemmed | Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title_short | Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique |
title_sort | determining response to treatment for drug-induced bronchocentric granulomatosis by the forced oscillation technique |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704422/ https://www.ncbi.nlm.nih.gov/pubmed/34946260 http://dx.doi.org/10.3390/medicina57121315 |
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