Ribosome Fate during Decoding of UGA-Sec Codons

Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation...

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Detalles Bibliográficos
Autores principales: Copeland, Paul R., Howard, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704476/
https://www.ncbi.nlm.nih.gov/pubmed/34948001
http://dx.doi.org/10.3390/ijms222413204
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author Copeland, Paul R.
Howard, Michael T.
author_facet Copeland, Paul R.
Howard, Michael T.
author_sort Copeland, Paul R.
collection PubMed
description Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.
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spelling pubmed-87044762021-12-25 Ribosome Fate during Decoding of UGA-Sec Codons Copeland, Paul R. Howard, Michael T. Int J Mol Sci Review Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine. MDPI 2021-12-08 /pmc/articles/PMC8704476/ /pubmed/34948001 http://dx.doi.org/10.3390/ijms222413204 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Copeland, Paul R.
Howard, Michael T.
Ribosome Fate during Decoding of UGA-Sec Codons
title Ribosome Fate during Decoding of UGA-Sec Codons
title_full Ribosome Fate during Decoding of UGA-Sec Codons
title_fullStr Ribosome Fate during Decoding of UGA-Sec Codons
title_full_unstemmed Ribosome Fate during Decoding of UGA-Sec Codons
title_short Ribosome Fate during Decoding of UGA-Sec Codons
title_sort ribosome fate during decoding of uga-sec codons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704476/
https://www.ncbi.nlm.nih.gov/pubmed/34948001
http://dx.doi.org/10.3390/ijms222413204
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