Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

Childhood-onset myocardial hypertrophy and cardiomyopathic changes are associated with significant morbidity and mortality in early life, particularly in patients with Noonan syndrome, a multisystemic genetic disorder caused by autosomal dominant mutations in genes of the Ras-MAPK pathway. Although...

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Detalles Bibliográficos
Autores principales: Meier, Anna B., Raj Murthi, Sarala, Rawat, Hilansi, Toepfer, Christopher N., Santamaria, Gianluca, Schmid, Manuel, Mastantuono, Elisa, Schwarzmayr, Thomas, Berutti, Riccardo, Cleuziou, Julie, Ewert, Peter, Görlach, Agnes, Klingel, Karin, Laugwitz, Karl-Ludwig, Seidman, Christine E., Seidman, Jonathan G., Moretti, Alessandra, Wolf, Cordula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704485/
https://www.ncbi.nlm.nih.gov/pubmed/34988410
http://dx.doi.org/10.1016/j.isci.2021.103596

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