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Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis

Objective: To identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease (IHD). Methods: The study included 80 patients: control group—20 men without IHD, the core group—60 men with IHD. The core group was divi...

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Autores principales: Shramko, Viktoriya S., Striukova, Eugeniia V., Polonskaya, Yana V., Stakhneva, Ekaterina M., Volkova, Marina V., Kurguzov, Alexey V., Kashtanova, Elena V., Ragino, Yuliya I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704768/
https://www.ncbi.nlm.nih.gov/pubmed/34945751
http://dx.doi.org/10.3390/jpm11121281
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author Shramko, Viktoriya S.
Striukova, Eugeniia V.
Polonskaya, Yana V.
Stakhneva, Ekaterina M.
Volkova, Marina V.
Kurguzov, Alexey V.
Kashtanova, Elena V.
Ragino, Yuliya I.
author_facet Shramko, Viktoriya S.
Striukova, Eugeniia V.
Polonskaya, Yana V.
Stakhneva, Ekaterina M.
Volkova, Marina V.
Kurguzov, Alexey V.
Kashtanova, Elena V.
Ragino, Yuliya I.
author_sort Shramko, Viktoriya S.
collection PubMed
description Objective: To identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease (IHD). Methods: The study included 80 patients: control group—20 men without IHD, the core group—60 men with IHD. The core group was divided into subgroups: subgroup A—with the presence of vulnerable atherosclerotic plaques, subgroup B—with the absence of vulnerable atherosclerotic plaques. We analyzed the levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the blood. Results. Patients with IHD, compared with the control group: (1) had higher levels of SOD, CAT, myristic, palmitic, palmitoleic, and octadecenoic FAs; (2) had lower levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic, and arachidonic FAs. In subgroup A there were found: (1) negative associations of SOD—with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations—with palmitic acid; (2) positive correlations of CAT level with palmitoleic and stearic acids; (3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs. Conclusions: Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels.
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spelling pubmed-87047682021-12-25 Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis Shramko, Viktoriya S. Striukova, Eugeniia V. Polonskaya, Yana V. Stakhneva, Ekaterina M. Volkova, Marina V. Kurguzov, Alexey V. Kashtanova, Elena V. Ragino, Yuliya I. J Pers Med Article Objective: To identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease (IHD). Methods: The study included 80 patients: control group—20 men without IHD, the core group—60 men with IHD. The core group was divided into subgroups: subgroup A—with the presence of vulnerable atherosclerotic plaques, subgroup B—with the absence of vulnerable atherosclerotic plaques. We analyzed the levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the blood. Results. Patients with IHD, compared with the control group: (1) had higher levels of SOD, CAT, myristic, palmitic, palmitoleic, and octadecenoic FAs; (2) had lower levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic, and arachidonic FAs. In subgroup A there were found: (1) negative associations of SOD—with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations—with palmitic acid; (2) positive correlations of CAT level with palmitoleic and stearic acids; (3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs. Conclusions: Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels. MDPI 2021-12-02 /pmc/articles/PMC8704768/ /pubmed/34945751 http://dx.doi.org/10.3390/jpm11121281 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shramko, Viktoriya S.
Striukova, Eugeniia V.
Polonskaya, Yana V.
Stakhneva, Ekaterina M.
Volkova, Marina V.
Kurguzov, Alexey V.
Kashtanova, Elena V.
Ragino, Yuliya I.
Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title_full Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title_fullStr Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title_full_unstemmed Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title_short Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis
title_sort associations of antioxidant enzymes with the concentration of fatty acids in the blood of men with coronary artery atherosclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704768/
https://www.ncbi.nlm.nih.gov/pubmed/34945751
http://dx.doi.org/10.3390/jpm11121281
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