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Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704770/ https://www.ncbi.nlm.nih.gov/pubmed/34940761 http://dx.doi.org/10.3390/ncrna7040081 |
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author | Skeparnias, Ilias Zhang, Jinwei |
author_facet | Skeparnias, Ilias Zhang, Jinwei |
author_sort | Skeparnias, Ilias |
collection | PubMed |
description | Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive. Herein, we discuss different modalities of RNA–RNA interactions with an emphasis on those that depend on secondary, tertiary, or quaternary structure. We dissect recently structurally elucidated RNA–RNA complexes including RNA triplexes, riboswitches, ribozymes, and reverse transcription complexes. These analyses highlight a reciprocal relationship that intimately links RNA structure formation with RNA–RNA interactions. The interactions not only shape and sculpt RNA structures but also are enabled and modulated by the structures they create. Understanding this two-way relationship between RNA structure and interactions provides mechanistic insights into the expanding repertoire of noncoding RNA functions, and may inform the design of novel therapeutics that target RNA structures or interactions. |
format | Online Article Text |
id | pubmed-8704770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87047702021-12-25 Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions Skeparnias, Ilias Zhang, Jinwei Noncoding RNA Review Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive. Herein, we discuss different modalities of RNA–RNA interactions with an emphasis on those that depend on secondary, tertiary, or quaternary structure. We dissect recently structurally elucidated RNA–RNA complexes including RNA triplexes, riboswitches, ribozymes, and reverse transcription complexes. These analyses highlight a reciprocal relationship that intimately links RNA structure formation with RNA–RNA interactions. The interactions not only shape and sculpt RNA structures but also are enabled and modulated by the structures they create. Understanding this two-way relationship between RNA structure and interactions provides mechanistic insights into the expanding repertoire of noncoding RNA functions, and may inform the design of novel therapeutics that target RNA structures or interactions. MDPI 2021-12-15 /pmc/articles/PMC8704770/ /pubmed/34940761 http://dx.doi.org/10.3390/ncrna7040081 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Skeparnias, Ilias Zhang, Jinwei Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title | Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title_full | Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title_fullStr | Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title_full_unstemmed | Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title_short | Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions |
title_sort | cooperativity and interdependency between rna structure and rna–rna interactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704770/ https://www.ncbi.nlm.nih.gov/pubmed/34940761 http://dx.doi.org/10.3390/ncrna7040081 |
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