Cargando…
The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression
Cell-signaling pathways are essential for cells to respond and adapt to changes in their environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces cerevisiae is activated by environmental stresses, compounds, and morphogenetic processes that compromise the cell wall, orchestra...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704918/ https://www.ncbi.nlm.nih.gov/pubmed/34947023 http://dx.doi.org/10.3390/jof7121041 |
_version_ | 1784621821501374464 |
---|---|
author | Quilis, Inma Gomar-Alba, Mercè Igual, Juan Carlos |
author_facet | Quilis, Inma Gomar-Alba, Mercè Igual, Juan Carlos |
author_sort | Quilis, Inma |
collection | PubMed |
description | Cell-signaling pathways are essential for cells to respond and adapt to changes in their environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces cerevisiae is activated by environmental stresses, compounds, and morphogenetic processes that compromise the cell wall, orchestrating the appropriate cellular response to cope with these adverse conditions. During cell-cycle progression, the CWI pathway is activated in periods of polarized growth, such as budding or cytokinesis, regulating cell-wall biosynthesis and the actin cytoskeleton. Importantly, accumulated evidence has indicated a reciprocal regulation of the cell-cycle regulatory system by the CWI pathway. In this paper, we describe how the CWI pathway regulates the main cell-cycle transitions in response to cell-surface perturbance to delay cell-cycle progression. In particular, it affects the Start transcriptional program and the initiation of DNA replication at the G1/S transition, and entry and progression through mitosis. We also describe the involvement of the CWI pathway in the response to genotoxic stress and its connection with the DNA integrity checkpoint, the mechanism that ensures the correct transmission of genetic material and cell survival. Thus, the CWI pathway emerges as a master brake that stops cell-cycle progression when cells are coping with distinct unfavorable conditions. |
format | Online Article Text |
id | pubmed-8704918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87049182021-12-25 The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression Quilis, Inma Gomar-Alba, Mercè Igual, Juan Carlos J Fungi (Basel) Review Cell-signaling pathways are essential for cells to respond and adapt to changes in their environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces cerevisiae is activated by environmental stresses, compounds, and morphogenetic processes that compromise the cell wall, orchestrating the appropriate cellular response to cope with these adverse conditions. During cell-cycle progression, the CWI pathway is activated in periods of polarized growth, such as budding or cytokinesis, regulating cell-wall biosynthesis and the actin cytoskeleton. Importantly, accumulated evidence has indicated a reciprocal regulation of the cell-cycle regulatory system by the CWI pathway. In this paper, we describe how the CWI pathway regulates the main cell-cycle transitions in response to cell-surface perturbance to delay cell-cycle progression. In particular, it affects the Start transcriptional program and the initiation of DNA replication at the G1/S transition, and entry and progression through mitosis. We also describe the involvement of the CWI pathway in the response to genotoxic stress and its connection with the DNA integrity checkpoint, the mechanism that ensures the correct transmission of genetic material and cell survival. Thus, the CWI pathway emerges as a master brake that stops cell-cycle progression when cells are coping with distinct unfavorable conditions. MDPI 2021-12-04 /pmc/articles/PMC8704918/ /pubmed/34947023 http://dx.doi.org/10.3390/jof7121041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Quilis, Inma Gomar-Alba, Mercè Igual, Juan Carlos The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title | The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title_full | The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title_fullStr | The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title_full_unstemmed | The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title_short | The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression |
title_sort | cwi pathway: a versatile toolbox to arrest cell-cycle progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704918/ https://www.ncbi.nlm.nih.gov/pubmed/34947023 http://dx.doi.org/10.3390/jof7121041 |
work_keys_str_mv | AT quilisinma thecwipathwayaversatiletoolboxtoarrestcellcycleprogression AT gomaralbamerce thecwipathwayaversatiletoolboxtoarrestcellcycleprogression AT igualjuancarlos thecwipathwayaversatiletoolboxtoarrestcellcycleprogression AT quilisinma cwipathwayaversatiletoolboxtoarrestcellcycleprogression AT gomaralbamerce cwipathwayaversatiletoolboxtoarrestcellcycleprogression AT igualjuancarlos cwipathwayaversatiletoolboxtoarrestcellcycleprogression |