TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor antigens with varying TCR signal strength. High-signal-strength interactions caused TST cells to up-regulate inhibitory re...

Descripción completa

Detalles Bibliográficos
Autores principales: Shakiba, Mojdeh, Zumbo, Paul, Espinosa-Carrasco, Gabriel, Menocal, Laura, Dündar, Friederike, Carson, Sandra E., Bruno, Emmanuel M., Sanchez-Rivera, Francisco J., Lowe, Scott W., Camara, Steven, Koche, Richard P., Reuter, Vincent P., Socci, Nicholas D., Whitlock, Benjamin, Tamzalit, Fella, Huse, Morgan, Hellmann, Matthew D., Wells, Daniel K., Defranoux, Nadine A., Betel, Doron, Philip, Mary, Schietinger, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704919/
https://www.ncbi.nlm.nih.gov/pubmed/34935874
http://dx.doi.org/10.1084/jem.20201966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704919/
https://www.ncbi.nlm.nih.gov/pubmed/34935874
http://dx.doi.org/10.1084/jem.20201966

Ejemplares similares