Cargando…
Complement System in Alzheimer’s Disease
Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than th...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705098/ https://www.ncbi.nlm.nih.gov/pubmed/34948444 http://dx.doi.org/10.3390/ijms222413647 |
_version_ | 1784621863864893440 |
---|---|
author | Shah, Akash Kishore, Uday Shastri, Abhishek |
author_facet | Shah, Akash Kishore, Uday Shastri, Abhishek |
author_sort | Shah, Akash |
collection | PubMed |
description | Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than thirty serum and membrane-bound proteins. This system has three different activating pathways and culminates into the formation of a membrane attack complex that ultimately causes target cell lysis (usually pathogens) The complement system is involved in several important functions in the central nervous system (CNS) that include neurogenesis, synaptic pruning, apoptosis, and neuronal plasticity. Here, we discuss how the complement system is involved in the effective functioning of CNS, while also contributing to chronic neuroinflammation leading to neurodegenerative disorders such as Alzheimer’s disease. We also discuss potential targets in the complement system for stopping its harmful effects via neuroinflammation and provide perspective for the direction of future research in this field. |
format | Online Article Text |
id | pubmed-8705098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87050982021-12-25 Complement System in Alzheimer’s Disease Shah, Akash Kishore, Uday Shastri, Abhishek Int J Mol Sci Review Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than thirty serum and membrane-bound proteins. This system has three different activating pathways and culminates into the formation of a membrane attack complex that ultimately causes target cell lysis (usually pathogens) The complement system is involved in several important functions in the central nervous system (CNS) that include neurogenesis, synaptic pruning, apoptosis, and neuronal plasticity. Here, we discuss how the complement system is involved in the effective functioning of CNS, while also contributing to chronic neuroinflammation leading to neurodegenerative disorders such as Alzheimer’s disease. We also discuss potential targets in the complement system for stopping its harmful effects via neuroinflammation and provide perspective for the direction of future research in this field. MDPI 2021-12-20 /pmc/articles/PMC8705098/ /pubmed/34948444 http://dx.doi.org/10.3390/ijms222413647 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shah, Akash Kishore, Uday Shastri, Abhishek Complement System in Alzheimer’s Disease |
title | Complement System in Alzheimer’s Disease |
title_full | Complement System in Alzheimer’s Disease |
title_fullStr | Complement System in Alzheimer’s Disease |
title_full_unstemmed | Complement System in Alzheimer’s Disease |
title_short | Complement System in Alzheimer’s Disease |
title_sort | complement system in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705098/ https://www.ncbi.nlm.nih.gov/pubmed/34948444 http://dx.doi.org/10.3390/ijms222413647 |
work_keys_str_mv | AT shahakash complementsysteminalzheimersdisease AT kishoreuday complementsysteminalzheimersdisease AT shastriabhishek complementsysteminalzheimersdisease |