An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

BACKGROUND: In addition to directly lysing tumors, oncolytic viruses also induce antitumor immunity by recruiting and activating immune cells in the local tumor microenvironment. However, the activation of the immune cells induced by oncolytic viruses is always accompanied by high-level expression o...

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Detalles Bibliográficos
Autores principales: Zuo, Shuguang, Wei, Min, Xu, Tiancheng, Kong, Lingkai, He, Bohao, Wang, Shiqun, Wang, Shibing, Wu, Junhua, Dong, Jie, Wei, Jiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705214/
https://www.ncbi.nlm.nih.gov/pubmed/34949694
http://dx.doi.org/10.1136/jitc-2021-002843

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