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Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice
Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705381/ https://www.ncbi.nlm.nih.gov/pubmed/34947929 http://dx.doi.org/10.3390/life11121398 |
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author | Baraibar-Churio, Arantxa Bobadilla, Míriam Machado, Florencio J. D. Sáinz, Neira Roncal, Carmen Abizanda, Gloria Prósper, Felipe Orbe, Josune Pérez-Ruiz, Ana |
author_facet | Baraibar-Churio, Arantxa Bobadilla, Míriam Machado, Florencio J. D. Sáinz, Neira Roncal, Carmen Abizanda, Gloria Prósper, Felipe Orbe, Josune Pérez-Ruiz, Ana |
author_sort | Baraibar-Churio, Arantxa |
collection | PubMed |
description | Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles. |
format | Online Article Text |
id | pubmed-8705381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87053812021-12-25 Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice Baraibar-Churio, Arantxa Bobadilla, Míriam Machado, Florencio J. D. Sáinz, Neira Roncal, Carmen Abizanda, Gloria Prósper, Felipe Orbe, Josune Pérez-Ruiz, Ana Life (Basel) Communication Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles. MDPI 2021-12-14 /pmc/articles/PMC8705381/ /pubmed/34947929 http://dx.doi.org/10.3390/life11121398 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Baraibar-Churio, Arantxa Bobadilla, Míriam Machado, Florencio J. D. Sáinz, Neira Roncal, Carmen Abizanda, Gloria Prósper, Felipe Orbe, Josune Pérez-Ruiz, Ana Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title | Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title_full | Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title_fullStr | Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title_full_unstemmed | Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title_short | Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice |
title_sort | deficiency of mmp-10 aggravates the diseased phenotype of aged dystrophic mice |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705381/ https://www.ncbi.nlm.nih.gov/pubmed/34947929 http://dx.doi.org/10.3390/life11121398 |
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