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Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications

In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning techniqu...

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Autores principales: Serbezeanu, Diana, Bargan, Alexandra, Homocianu, Mihaela, Aflori, Magdalena, Rîmbu, Cristina Mihaela, Enache, Alexandru Alin, Vlad-Bubulac, Tăchiță
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705401/
https://www.ncbi.nlm.nih.gov/pubmed/34947686
http://dx.doi.org/10.3390/nano11123336
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author Serbezeanu, Diana
Bargan, Alexandra
Homocianu, Mihaela
Aflori, Magdalena
Rîmbu, Cristina Mihaela
Enache, Alexandru Alin
Vlad-Bubulac, Tăchiță
author_facet Serbezeanu, Diana
Bargan, Alexandra
Homocianu, Mihaela
Aflori, Magdalena
Rîmbu, Cristina Mihaela
Enache, Alexandru Alin
Vlad-Bubulac, Tăchiță
author_sort Serbezeanu, Diana
collection PubMed
description In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning technique. The chemical structure and morphology of the polymeric nanofibers were investigated using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The addition of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba extracts to the pure polyvinyl alcohol fibers led to changes in the morphology of the fibers and a reduction in the fibers’ diameter, from 0.1798 µm in the case of pure polyvinyl alcohol to 0.1672, 0.1425, and 0.1369 µm in the case of polyvinyl alcohol loaded with Thymus vulgaris, Salvia officinalis folium, and Hyperici herba, respectively. The adapted Folin–Ciocalteu (FC) method, which was used to determine the total phenolic contents, revealed that the samples of PVA–Hyperici herba and PVA–Thymus vulgaris had the highest phenol contents, at 13.25 μgGAE/mL and 12.66 μgGAE/mL, respectively. Dynamic water vapor measurements were used in order to investigate the moisture sorption and desorption behavior of the developed electrospun materials. The antimicrobial behavior of these products was also evaluated. Disk diffusion assay studies with Escherichia coli, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus were conducted on the developed nanofibers in order to quantify their phytotherapeutic potential.
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spelling pubmed-87054012021-12-25 Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications Serbezeanu, Diana Bargan, Alexandra Homocianu, Mihaela Aflori, Magdalena Rîmbu, Cristina Mihaela Enache, Alexandru Alin Vlad-Bubulac, Tăchiță Nanomaterials (Basel) Article In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning technique. The chemical structure and morphology of the polymeric nanofibers were investigated using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The addition of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba extracts to the pure polyvinyl alcohol fibers led to changes in the morphology of the fibers and a reduction in the fibers’ diameter, from 0.1798 µm in the case of pure polyvinyl alcohol to 0.1672, 0.1425, and 0.1369 µm in the case of polyvinyl alcohol loaded with Thymus vulgaris, Salvia officinalis folium, and Hyperici herba, respectively. The adapted Folin–Ciocalteu (FC) method, which was used to determine the total phenolic contents, revealed that the samples of PVA–Hyperici herba and PVA–Thymus vulgaris had the highest phenol contents, at 13.25 μgGAE/mL and 12.66 μgGAE/mL, respectively. Dynamic water vapor measurements were used in order to investigate the moisture sorption and desorption behavior of the developed electrospun materials. The antimicrobial behavior of these products was also evaluated. Disk diffusion assay studies with Escherichia coli, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus were conducted on the developed nanofibers in order to quantify their phytotherapeutic potential. MDPI 2021-12-08 /pmc/articles/PMC8705401/ /pubmed/34947686 http://dx.doi.org/10.3390/nano11123336 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serbezeanu, Diana
Bargan, Alexandra
Homocianu, Mihaela
Aflori, Magdalena
Rîmbu, Cristina Mihaela
Enache, Alexandru Alin
Vlad-Bubulac, Tăchiță
Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title_full Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title_fullStr Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title_full_unstemmed Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title_short Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
title_sort electrospun polyvinyl alcohol loaded with phytotherapeutic agents for wound healing applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705401/
https://www.ncbi.nlm.nih.gov/pubmed/34947686
http://dx.doi.org/10.3390/nano11123336
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