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Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications
In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning techniqu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705401/ https://www.ncbi.nlm.nih.gov/pubmed/34947686 http://dx.doi.org/10.3390/nano11123336 |
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author | Serbezeanu, Diana Bargan, Alexandra Homocianu, Mihaela Aflori, Magdalena Rîmbu, Cristina Mihaela Enache, Alexandru Alin Vlad-Bubulac, Tăchiță |
author_facet | Serbezeanu, Diana Bargan, Alexandra Homocianu, Mihaela Aflori, Magdalena Rîmbu, Cristina Mihaela Enache, Alexandru Alin Vlad-Bubulac, Tăchiță |
author_sort | Serbezeanu, Diana |
collection | PubMed |
description | In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning technique. The chemical structure and morphology of the polymeric nanofibers were investigated using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The addition of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba extracts to the pure polyvinyl alcohol fibers led to changes in the morphology of the fibers and a reduction in the fibers’ diameter, from 0.1798 µm in the case of pure polyvinyl alcohol to 0.1672, 0.1425, and 0.1369 µm in the case of polyvinyl alcohol loaded with Thymus vulgaris, Salvia officinalis folium, and Hyperici herba, respectively. The adapted Folin–Ciocalteu (FC) method, which was used to determine the total phenolic contents, revealed that the samples of PVA–Hyperici herba and PVA–Thymus vulgaris had the highest phenol contents, at 13.25 μgGAE/mL and 12.66 μgGAE/mL, respectively. Dynamic water vapor measurements were used in order to investigate the moisture sorption and desorption behavior of the developed electrospun materials. The antimicrobial behavior of these products was also evaluated. Disk diffusion assay studies with Escherichia coli, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus were conducted on the developed nanofibers in order to quantify their phytotherapeutic potential. |
format | Online Article Text |
id | pubmed-8705401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87054012021-12-25 Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications Serbezeanu, Diana Bargan, Alexandra Homocianu, Mihaela Aflori, Magdalena Rîmbu, Cristina Mihaela Enache, Alexandru Alin Vlad-Bubulac, Tăchiță Nanomaterials (Basel) Article In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning technique. The chemical structure and morphology of the polymeric nanofibers were investigated using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The addition of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba extracts to the pure polyvinyl alcohol fibers led to changes in the morphology of the fibers and a reduction in the fibers’ diameter, from 0.1798 µm in the case of pure polyvinyl alcohol to 0.1672, 0.1425, and 0.1369 µm in the case of polyvinyl alcohol loaded with Thymus vulgaris, Salvia officinalis folium, and Hyperici herba, respectively. The adapted Folin–Ciocalteu (FC) method, which was used to determine the total phenolic contents, revealed that the samples of PVA–Hyperici herba and PVA–Thymus vulgaris had the highest phenol contents, at 13.25 μgGAE/mL and 12.66 μgGAE/mL, respectively. Dynamic water vapor measurements were used in order to investigate the moisture sorption and desorption behavior of the developed electrospun materials. The antimicrobial behavior of these products was also evaluated. Disk diffusion assay studies with Escherichia coli, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus were conducted on the developed nanofibers in order to quantify their phytotherapeutic potential. MDPI 2021-12-08 /pmc/articles/PMC8705401/ /pubmed/34947686 http://dx.doi.org/10.3390/nano11123336 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Serbezeanu, Diana Bargan, Alexandra Homocianu, Mihaela Aflori, Magdalena Rîmbu, Cristina Mihaela Enache, Alexandru Alin Vlad-Bubulac, Tăchiță Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title | Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title_full | Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title_fullStr | Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title_full_unstemmed | Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title_short | Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications |
title_sort | electrospun polyvinyl alcohol loaded with phytotherapeutic agents for wound healing applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705401/ https://www.ncbi.nlm.nih.gov/pubmed/34947686 http://dx.doi.org/10.3390/nano11123336 |
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