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Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases

In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physi...

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Autores principales: Ramos-Martínez, Ivan Emmanuel, Rodríguez, María Carmen, Cerbón, Marco, Ramos-Martínez, Juan Carlos, Ramos-Martínez, Edgar Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705572/
https://www.ncbi.nlm.nih.gov/pubmed/34948222
http://dx.doi.org/10.3390/ijms222413427
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author Ramos-Martínez, Ivan Emmanuel
Rodríguez, María Carmen
Cerbón, Marco
Ramos-Martínez, Juan Carlos
Ramos-Martínez, Edgar Gustavo
author_facet Ramos-Martínez, Ivan Emmanuel
Rodríguez, María Carmen
Cerbón, Marco
Ramos-Martínez, Juan Carlos
Ramos-Martínez, Edgar Gustavo
author_sort Ramos-Martínez, Ivan Emmanuel
collection PubMed
description In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation.
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spelling pubmed-87055722021-12-25 Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases Ramos-Martínez, Ivan Emmanuel Rodríguez, María Carmen Cerbón, Marco Ramos-Martínez, Juan Carlos Ramos-Martínez, Edgar Gustavo Int J Mol Sci Review In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation. MDPI 2021-12-14 /pmc/articles/PMC8705572/ /pubmed/34948222 http://dx.doi.org/10.3390/ijms222413427 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramos-Martínez, Ivan Emmanuel
Rodríguez, María Carmen
Cerbón, Marco
Ramos-Martínez, Juan Carlos
Ramos-Martínez, Edgar Gustavo
Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title_full Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title_fullStr Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title_full_unstemmed Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title_short Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
title_sort role of the cholinergic anti-inflammatory reflex in central nervous system diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705572/
https://www.ncbi.nlm.nih.gov/pubmed/34948222
http://dx.doi.org/10.3390/ijms222413427
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