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Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705572/ https://www.ncbi.nlm.nih.gov/pubmed/34948222 http://dx.doi.org/10.3390/ijms222413427 |
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author | Ramos-Martínez, Ivan Emmanuel Rodríguez, María Carmen Cerbón, Marco Ramos-Martínez, Juan Carlos Ramos-Martínez, Edgar Gustavo |
author_facet | Ramos-Martínez, Ivan Emmanuel Rodríguez, María Carmen Cerbón, Marco Ramos-Martínez, Juan Carlos Ramos-Martínez, Edgar Gustavo |
author_sort | Ramos-Martínez, Ivan Emmanuel |
collection | PubMed |
description | In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation. |
format | Online Article Text |
id | pubmed-8705572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87055722021-12-25 Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases Ramos-Martínez, Ivan Emmanuel Rodríguez, María Carmen Cerbón, Marco Ramos-Martínez, Juan Carlos Ramos-Martínez, Edgar Gustavo Int J Mol Sci Review In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation. MDPI 2021-12-14 /pmc/articles/PMC8705572/ /pubmed/34948222 http://dx.doi.org/10.3390/ijms222413427 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ramos-Martínez, Ivan Emmanuel Rodríguez, María Carmen Cerbón, Marco Ramos-Martínez, Juan Carlos Ramos-Martínez, Edgar Gustavo Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title | Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title_full | Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title_fullStr | Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title_full_unstemmed | Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title_short | Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases |
title_sort | role of the cholinergic anti-inflammatory reflex in central nervous system diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705572/ https://www.ncbi.nlm.nih.gov/pubmed/34948222 http://dx.doi.org/10.3390/ijms222413427 |
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