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Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales

Neonatal jaundice, caused by excess serum bilirubin levels, is a common condition in neonates. Imbalance in the gut microbiota is believed to play a role in the development of neonatal jaundice. Thus, we aimed to reveal the gut microbiota characteristics in neonates with jaundice. 16S rRNA gene sequ...

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Autores principales: Akagawa, Shohei, Akagawa, Yuko, Yamanouchi, Sohsaku, Teramoto, Yoshiki, Yasuda, Masahiro, Fujishiro, Sadayuki, Kino, Jiro, Hirabayashi, Masato, Mine, Kenji, Kimata, Takahisa, Hashiyada, Masaki, Akane, Atsushi, Tsuji, Shoji, Kaneko, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705620/
https://www.ncbi.nlm.nih.gov/pubmed/34940645
http://dx.doi.org/10.3390/metabo11120887
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author Akagawa, Shohei
Akagawa, Yuko
Yamanouchi, Sohsaku
Teramoto, Yoshiki
Yasuda, Masahiro
Fujishiro, Sadayuki
Kino, Jiro
Hirabayashi, Masato
Mine, Kenji
Kimata, Takahisa
Hashiyada, Masaki
Akane, Atsushi
Tsuji, Shoji
Kaneko, Kazunari
author_facet Akagawa, Shohei
Akagawa, Yuko
Yamanouchi, Sohsaku
Teramoto, Yoshiki
Yasuda, Masahiro
Fujishiro, Sadayuki
Kino, Jiro
Hirabayashi, Masato
Mine, Kenji
Kimata, Takahisa
Hashiyada, Masaki
Akane, Atsushi
Tsuji, Shoji
Kaneko, Kazunari
author_sort Akagawa, Shohei
collection PubMed
description Neonatal jaundice, caused by excess serum bilirubin levels, is a common condition in neonates. Imbalance in the gut microbiota is believed to play a role in the development of neonatal jaundice. Thus, we aimed to reveal the gut microbiota characteristics in neonates with jaundice. 16S rRNA gene sequencing was performed on stool samples collected on day 4 from 26 neonates with jaundice (serum total bilirubin > 15.0 mg/dL) and 17 neonates without jaundice (total serum bilirubin < 10.0 mg/dL). All neonates were born full term, with normal weight, by vaginal delivery, and were breastfed. Neonates who were administered antibiotics, had serum direct bilirubin levels above 1 mg/dL, or had conditions possibly leading to hemolytic anemia were excluded. The median serum bilirubin was 16.0 mg/dL (interquartile range: 15.5–16.8) and 7.4 mg/dL (interquartile range: 6.8–8.3) for the jaundice and non-jaundice groups, respectively. There was no difference in the alpha diversity indices. Meanwhile, in the jaundice group, linear discriminant analysis effect size revealed that Bifidobacteriales were decreased at the order level, while Enterococcaceae were increased and Bifidobacteriaceae were decreased at the family level. Bifidobacteriaceae may act preventatively because of their suppressive effect on beta-glucuronidase, leading to accelerated deconjugation of conjugated bilirubin in the intestine. In summary, neonates with jaundice had dysbiosis characterized by a decreased abundance of Bifidobacteriales.
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spelling pubmed-87056202021-12-25 Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales Akagawa, Shohei Akagawa, Yuko Yamanouchi, Sohsaku Teramoto, Yoshiki Yasuda, Masahiro Fujishiro, Sadayuki Kino, Jiro Hirabayashi, Masato Mine, Kenji Kimata, Takahisa Hashiyada, Masaki Akane, Atsushi Tsuji, Shoji Kaneko, Kazunari Metabolites Article Neonatal jaundice, caused by excess serum bilirubin levels, is a common condition in neonates. Imbalance in the gut microbiota is believed to play a role in the development of neonatal jaundice. Thus, we aimed to reveal the gut microbiota characteristics in neonates with jaundice. 16S rRNA gene sequencing was performed on stool samples collected on day 4 from 26 neonates with jaundice (serum total bilirubin > 15.0 mg/dL) and 17 neonates without jaundice (total serum bilirubin < 10.0 mg/dL). All neonates were born full term, with normal weight, by vaginal delivery, and were breastfed. Neonates who were administered antibiotics, had serum direct bilirubin levels above 1 mg/dL, or had conditions possibly leading to hemolytic anemia were excluded. The median serum bilirubin was 16.0 mg/dL (interquartile range: 15.5–16.8) and 7.4 mg/dL (interquartile range: 6.8–8.3) for the jaundice and non-jaundice groups, respectively. There was no difference in the alpha diversity indices. Meanwhile, in the jaundice group, linear discriminant analysis effect size revealed that Bifidobacteriales were decreased at the order level, while Enterococcaceae were increased and Bifidobacteriaceae were decreased at the family level. Bifidobacteriaceae may act preventatively because of their suppressive effect on beta-glucuronidase, leading to accelerated deconjugation of conjugated bilirubin in the intestine. In summary, neonates with jaundice had dysbiosis characterized by a decreased abundance of Bifidobacteriales. MDPI 2021-12-18 /pmc/articles/PMC8705620/ /pubmed/34940645 http://dx.doi.org/10.3390/metabo11120887 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Akagawa, Shohei
Akagawa, Yuko
Yamanouchi, Sohsaku
Teramoto, Yoshiki
Yasuda, Masahiro
Fujishiro, Sadayuki
Kino, Jiro
Hirabayashi, Masato
Mine, Kenji
Kimata, Takahisa
Hashiyada, Masaki
Akane, Atsushi
Tsuji, Shoji
Kaneko, Kazunari
Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title_full Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title_fullStr Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title_full_unstemmed Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title_short Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales
title_sort association of neonatal jaundice with gut dysbiosis characterized by decreased bifidobacteriales
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705620/
https://www.ncbi.nlm.nih.gov/pubmed/34940645
http://dx.doi.org/10.3390/metabo11120887
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