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Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common, chronic, functional disorder with a large impact on world population. Its pathophysiology is not completely revealed; however, it is certain that dysregulation of the bidirectional communications between the central nervous system (CNS) and the gut leads t...

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Autores principales: Wollny, Tomasz, Daniluk, Tamara, Piktel, Ewelina, Wnorowska, Urszula, Bukłaha, Anna, Głuszek, Katarzyna, Durnaś, Bonita, Bucki, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705654/
https://www.ncbi.nlm.nih.gov/pubmed/34959500
http://dx.doi.org/10.3390/pathogens10121545
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author Wollny, Tomasz
Daniluk, Tamara
Piktel, Ewelina
Wnorowska, Urszula
Bukłaha, Anna
Głuszek, Katarzyna
Durnaś, Bonita
Bucki, Robert
author_facet Wollny, Tomasz
Daniluk, Tamara
Piktel, Ewelina
Wnorowska, Urszula
Bukłaha, Anna
Głuszek, Katarzyna
Durnaś, Bonita
Bucki, Robert
author_sort Wollny, Tomasz
collection PubMed
description Irritable bowel syndrome (IBS) is a common, chronic, functional disorder with a large impact on world population. Its pathophysiology is not completely revealed; however, it is certain that dysregulation of the bidirectional communications between the central nervous system (CNS) and the gut leads to motility disturbances, visceral hypersensitivity, and altered CNS processing characterized by differences in brain structure, connectivity and functional responsiveness. Emerging evidence suggests that gut microbiota exerts a marked influence on the host during health and disease. Gut microbiome disturbances can be also important for development of IBS symptoms and its modulation efficiently contributes to the therapy. In this work, we review the current knowledge about the IBS therapy, the role of gut microbiota in pathogenesis of IBS, and we discuss that its targeting may have significant impact on the effectiveness of IBS therapy.
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spelling pubmed-87056542021-12-25 Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome Wollny, Tomasz Daniluk, Tamara Piktel, Ewelina Wnorowska, Urszula Bukłaha, Anna Głuszek, Katarzyna Durnaś, Bonita Bucki, Robert Pathogens Review Irritable bowel syndrome (IBS) is a common, chronic, functional disorder with a large impact on world population. Its pathophysiology is not completely revealed; however, it is certain that dysregulation of the bidirectional communications between the central nervous system (CNS) and the gut leads to motility disturbances, visceral hypersensitivity, and altered CNS processing characterized by differences in brain structure, connectivity and functional responsiveness. Emerging evidence suggests that gut microbiota exerts a marked influence on the host during health and disease. Gut microbiome disturbances can be also important for development of IBS symptoms and its modulation efficiently contributes to the therapy. In this work, we review the current knowledge about the IBS therapy, the role of gut microbiota in pathogenesis of IBS, and we discuss that its targeting may have significant impact on the effectiveness of IBS therapy. MDPI 2021-11-25 /pmc/articles/PMC8705654/ /pubmed/34959500 http://dx.doi.org/10.3390/pathogens10121545 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wollny, Tomasz
Daniluk, Tamara
Piktel, Ewelina
Wnorowska, Urszula
Bukłaha, Anna
Głuszek, Katarzyna
Durnaś, Bonita
Bucki, Robert
Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title_full Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title_fullStr Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title_full_unstemmed Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title_short Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome
title_sort targeting the gut microbiota to relieve the symptoms of irritable bowel syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705654/
https://www.ncbi.nlm.nih.gov/pubmed/34959500
http://dx.doi.org/10.3390/pathogens10121545
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