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Tethered Aryl Groups Increase the Activity of Anti-Proliferative Thieno[2,3-b]Pyridines by Targeting a Lipophilic Region in the Active Site of PI-PLC

The compounds 2-amino-3-carboxamido-thieno[2,3-b]pyridines have demonstrated excellent anti-proliferative activity against human cancer cell lines, including the triple-negative breast cancer cell line MDA-MB-231. In this study, 81 novel thieno[2,3-b]pyridines were synthesised in four series to furt...

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Detalles Bibliográficos
Autores principales:	Haverkate, Natalie A., Leung, Euphemia, Pilkington, Lisa I., Barker, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705770/ https://www.ncbi.nlm.nih.gov/pubmed/34959302 http://dx.doi.org/10.3390/pharmaceutics13122020

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