Cargando…
Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linea...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705772/ https://www.ncbi.nlm.nih.gov/pubmed/34947877 http://dx.doi.org/10.3390/life11121346 |
_version_ | 1784622029399392256 |
---|---|
author | Kotłowski, Roman |
author_facet | Kotłowski, Roman |
author_sort | Kotłowski, Roman |
collection | PubMed |
description | The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions. |
format | Online Article Text |
id | pubmed-8705772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87057722021-12-25 Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes Kotłowski, Roman Life (Basel) Communication The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions. MDPI 2021-12-05 /pmc/articles/PMC8705772/ /pubmed/34947877 http://dx.doi.org/10.3390/life11121346 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Kotłowski, Roman Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title | Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title_full | Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title_fullStr | Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title_full_unstemmed | Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title_short | Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes |
title_sort | influence of escherichia coli on expression of selected human drug addiction genes |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705772/ https://www.ncbi.nlm.nih.gov/pubmed/34947877 http://dx.doi.org/10.3390/life11121346 |
work_keys_str_mv | AT kotłowskiroman influenceofescherichiacolionexpressionofselectedhumandrugaddictiongenes |