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Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes

The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linea...

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Autor principal: Kotłowski, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705772/
https://www.ncbi.nlm.nih.gov/pubmed/34947877
http://dx.doi.org/10.3390/life11121346
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author Kotłowski, Roman
author_facet Kotłowski, Roman
author_sort Kotłowski, Roman
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description The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions.
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spelling pubmed-87057722021-12-25 Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes Kotłowski, Roman Life (Basel) Communication The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions. MDPI 2021-12-05 /pmc/articles/PMC8705772/ /pubmed/34947877 http://dx.doi.org/10.3390/life11121346 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kotłowski, Roman
Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title_full Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title_fullStr Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title_full_unstemmed Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title_short Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
title_sort influence of escherichia coli on expression of selected human drug addiction genes
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705772/
https://www.ncbi.nlm.nih.gov/pubmed/34947877
http://dx.doi.org/10.3390/life11121346
work_keys_str_mv AT kotłowskiroman influenceofescherichiacolionexpressionofselectedhumandrugaddictiongenes