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Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation

Niemann-Pick type C disease (NPC) is a rare inherited neurodegenerative disorder characterized by an accumulation of intracellular cholesterol within late endosomes and lysosomes due to NPC1 or NPC2 dysfunction. In this work, we tested the hypothesis that retromer impairment may be involved in the p...

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Detalles Bibliográficos
Autores principales:	Dominko, Kristina, Rastija, Ana, Sobocanec, Sandra, Vidatic, Lea, Meglaj, Sarah, Lovincic Babic, Andrea, Hutter-Paier, Birgit, Colombo, Alessio-Vittorio, Lichtenthaler, Stefan F., Tahirovic, Sabina, Hecimovic, Silva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705785/ https://www.ncbi.nlm.nih.gov/pubmed/34948052 http://dx.doi.org/10.3390/ijms222413256

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