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Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review

Vitamin D has a promising role in multiple sclerosis (MS) management, and it has been found to be beneficial for patients’ mental health, which is reduced in MS patients. The aim of the present study was to conduct a systematic review of the literature to assess the influence of vitamin D supplement...

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Autores principales: Głąbska, Dominika, Kołota, Aleksandra, Lachowicz, Katarzyna, Skolmowska, Dominika, Stachoń, Małgorzata, Guzek, Dominika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705844/
https://www.ncbi.nlm.nih.gov/pubmed/34959758
http://dx.doi.org/10.3390/nu13124207
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author Głąbska, Dominika
Kołota, Aleksandra
Lachowicz, Katarzyna
Skolmowska, Dominika
Stachoń, Małgorzata
Guzek, Dominika
author_facet Głąbska, Dominika
Kołota, Aleksandra
Lachowicz, Katarzyna
Skolmowska, Dominika
Stachoń, Małgorzata
Guzek, Dominika
author_sort Głąbska, Dominika
collection PubMed
description Vitamin D has a promising role in multiple sclerosis (MS) management, and it has been found to be beneficial for patients’ mental health, which is reduced in MS patients. The aim of the present study was to conduct a systematic review of the literature to assess the influence of vitamin D supplementation on mental health in MS patients. The systematic review was registered in the PROSPERO database (CRD42020155779) and it was conducted on the basis of the PRISMA guidelines. The search procedure was conducted using PubMed and Web of Science databases and it included studies published up until September 2021. Six studies were included in the systematic review. The risk of bias was analyzed using the Newcastle–Ottawa Scale (NOS). Within the included studies, there were two studies randomized against placebo and four other prospective studies. The studies presented vitamin D interventions randomized against placebo or not randomized, while supplementation was applied for various durations—from 4 weeks to 12 months, or the studies compared patients who applied vitamin D supplementation and those who did not apply it and verified the effect of the supplementation after a number of years. The mental health outcomes that were assessed included quality of life, depression/depressive symptoms, and fatigue as an additional element. The majority of studies supported the positive influence of vitamin D on the mental health of MS patients, including the study characterized as having the highest quality (randomized against placebo with the highest NOS score). All the studies that assessed the quality of life indicated the positive influence of vitamin D while the studies that did not find a positive influence of vitamin D were conducted for depression/depressive symptoms. In spite of the fact that only a small number of studies have been conducted so far, and only two studies were randomized against a placebo, some conclusions may be formulated. The systematic review allowed us to conclude that there may be a positive effect of vitamin D supplementation in MS patients, which was stated in all of the studies analyzing quality of life, as well as in one study analyzing depressive symptoms. Considering that vitamin D deficiency is common in MS patients, and the potential positive influence of supplementation on the quality of life, supplementation should be applied at least in doses that cover the recommended intake.
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spelling pubmed-87058442021-12-25 Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review Głąbska, Dominika Kołota, Aleksandra Lachowicz, Katarzyna Skolmowska, Dominika Stachoń, Małgorzata Guzek, Dominika Nutrients Systematic Review Vitamin D has a promising role in multiple sclerosis (MS) management, and it has been found to be beneficial for patients’ mental health, which is reduced in MS patients. The aim of the present study was to conduct a systematic review of the literature to assess the influence of vitamin D supplementation on mental health in MS patients. The systematic review was registered in the PROSPERO database (CRD42020155779) and it was conducted on the basis of the PRISMA guidelines. The search procedure was conducted using PubMed and Web of Science databases and it included studies published up until September 2021. Six studies were included in the systematic review. The risk of bias was analyzed using the Newcastle–Ottawa Scale (NOS). Within the included studies, there were two studies randomized against placebo and four other prospective studies. The studies presented vitamin D interventions randomized against placebo or not randomized, while supplementation was applied for various durations—from 4 weeks to 12 months, or the studies compared patients who applied vitamin D supplementation and those who did not apply it and verified the effect of the supplementation after a number of years. The mental health outcomes that were assessed included quality of life, depression/depressive symptoms, and fatigue as an additional element. The majority of studies supported the positive influence of vitamin D on the mental health of MS patients, including the study characterized as having the highest quality (randomized against placebo with the highest NOS score). All the studies that assessed the quality of life indicated the positive influence of vitamin D while the studies that did not find a positive influence of vitamin D were conducted for depression/depressive symptoms. In spite of the fact that only a small number of studies have been conducted so far, and only two studies were randomized against a placebo, some conclusions may be formulated. The systematic review allowed us to conclude that there may be a positive effect of vitamin D supplementation in MS patients, which was stated in all of the studies analyzing quality of life, as well as in one study analyzing depressive symptoms. Considering that vitamin D deficiency is common in MS patients, and the potential positive influence of supplementation on the quality of life, supplementation should be applied at least in doses that cover the recommended intake. MDPI 2021-11-24 /pmc/articles/PMC8705844/ /pubmed/34959758 http://dx.doi.org/10.3390/nu13124207 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Głąbska, Dominika
Kołota, Aleksandra
Lachowicz, Katarzyna
Skolmowska, Dominika
Stachoń, Małgorzata
Guzek, Dominika
Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title_full Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title_fullStr Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title_full_unstemmed Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title_short Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review
title_sort vitamin d supplementation and mental health in multiple sclerosis patients: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705844/
https://www.ncbi.nlm.nih.gov/pubmed/34959758
http://dx.doi.org/10.3390/nu13124207
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