The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation t...

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Detalles Bibliográficos
Autores principales: Bobal, Pavel, Lastovickova, Marketa, Bobalova, Janette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705994/
https://www.ncbi.nlm.nih.gov/pubmed/34948142
http://dx.doi.org/10.3390/ijms222413345
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author Bobal, Pavel
Lastovickova, Marketa
Bobalova, Janette
author_facet Bobal, Pavel
Lastovickova, Marketa
Bobalova, Janette
author_sort Bobal, Pavel
collection PubMed
description The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.
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spelling pubmed-87059942021-12-25 The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview Bobal, Pavel Lastovickova, Marketa Bobalova, Janette Int J Mol Sci Review The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death. MDPI 2021-12-12 /pmc/articles/PMC8705994/ /pubmed/34948142 http://dx.doi.org/10.3390/ijms222413345 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bobal, Pavel
Lastovickova, Marketa
Bobalova, Janette
The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title_full The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title_fullStr The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title_full_unstemmed The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title_short The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
title_sort role of atra, natural ligand of retinoic acid receptors, on emt-related proteins in breast cancer: minireview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705994/
https://www.ncbi.nlm.nih.gov/pubmed/34948142
http://dx.doi.org/10.3390/ijms222413345
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