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An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management

Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based o...

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Autores principales: Tudoroiu, Elena-Emilia, Dinu-Pîrvu, Cristina-Elena, Albu Kaya, Mădălina Georgiana, Popa, Lăcrămioara, Anuța, Valentina, Prisada, Răzvan Mihai, Ghica, Mihaela Violeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706040/
https://www.ncbi.nlm.nih.gov/pubmed/34959615
http://dx.doi.org/10.3390/ph14121215
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author Tudoroiu, Elena-Emilia
Dinu-Pîrvu, Cristina-Elena
Albu Kaya, Mădălina Georgiana
Popa, Lăcrămioara
Anuța, Valentina
Prisada, Răzvan Mihai
Ghica, Mihaela Violeta
author_facet Tudoroiu, Elena-Emilia
Dinu-Pîrvu, Cristina-Elena
Albu Kaya, Mădălina Georgiana
Popa, Lăcrămioara
Anuța, Valentina
Prisada, Răzvan Mihai
Ghica, Mihaela Violeta
author_sort Tudoroiu, Elena-Emilia
collection PubMed
description Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering.
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spelling pubmed-87060402021-12-25 An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management Tudoroiu, Elena-Emilia Dinu-Pîrvu, Cristina-Elena Albu Kaya, Mădălina Georgiana Popa, Lăcrămioara Anuța, Valentina Prisada, Răzvan Mihai Ghica, Mihaela Violeta Pharmaceuticals (Basel) Review Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering. MDPI 2021-11-24 /pmc/articles/PMC8706040/ /pubmed/34959615 http://dx.doi.org/10.3390/ph14121215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tudoroiu, Elena-Emilia
Dinu-Pîrvu, Cristina-Elena
Albu Kaya, Mădălina Georgiana
Popa, Lăcrămioara
Anuța, Valentina
Prisada, Răzvan Mihai
Ghica, Mihaela Violeta
An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title_full An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title_fullStr An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title_full_unstemmed An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title_short An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
title_sort overview of cellulose derivatives-based dressings for wound-healing management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706040/
https://www.ncbi.nlm.nih.gov/pubmed/34959615
http://dx.doi.org/10.3390/ph14121215
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