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An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706040/ https://www.ncbi.nlm.nih.gov/pubmed/34959615 http://dx.doi.org/10.3390/ph14121215 |
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author | Tudoroiu, Elena-Emilia Dinu-Pîrvu, Cristina-Elena Albu Kaya, Mădălina Georgiana Popa, Lăcrămioara Anuța, Valentina Prisada, Răzvan Mihai Ghica, Mihaela Violeta |
author_facet | Tudoroiu, Elena-Emilia Dinu-Pîrvu, Cristina-Elena Albu Kaya, Mădălina Georgiana Popa, Lăcrămioara Anuța, Valentina Prisada, Răzvan Mihai Ghica, Mihaela Violeta |
author_sort | Tudoroiu, Elena-Emilia |
collection | PubMed |
description | Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering. |
format | Online Article Text |
id | pubmed-8706040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87060402021-12-25 An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management Tudoroiu, Elena-Emilia Dinu-Pîrvu, Cristina-Elena Albu Kaya, Mădălina Georgiana Popa, Lăcrămioara Anuța, Valentina Prisada, Răzvan Mihai Ghica, Mihaela Violeta Pharmaceuticals (Basel) Review Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering. MDPI 2021-11-24 /pmc/articles/PMC8706040/ /pubmed/34959615 http://dx.doi.org/10.3390/ph14121215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tudoroiu, Elena-Emilia Dinu-Pîrvu, Cristina-Elena Albu Kaya, Mădălina Georgiana Popa, Lăcrămioara Anuța, Valentina Prisada, Răzvan Mihai Ghica, Mihaela Violeta An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title_full | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title_fullStr | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title_full_unstemmed | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title_short | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
title_sort | overview of cellulose derivatives-based dressings for wound-healing management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706040/ https://www.ncbi.nlm.nih.gov/pubmed/34959615 http://dx.doi.org/10.3390/ph14121215 |
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