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Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems
Declines in physiological functions are the predominant risk factors for age-related diseases, such as cancers and neurodegenerative diseases. Therefore, delaying the aging process is believed to be beneficial in preventing the onset of age-related diseases. Previous studies have demonstrated that G...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706064/ https://www.ncbi.nlm.nih.gov/pubmed/34959868 http://dx.doi.org/10.3390/nu13124317 |
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author | Chen, Yan-Xi Le, Phuong Thu Nguyen Tzeng, Tsai-Teng Tran, Thu-Ha Nguyen, Anh Thuc Cheng, Irene Han-Juo Huang, Chi-Ying F. Shiao, Young-Ji Ching, Tsui-Ting |
author_facet | Chen, Yan-Xi Le, Phuong Thu Nguyen Tzeng, Tsai-Teng Tran, Thu-Ha Nguyen, Anh Thuc Cheng, Irene Han-Juo Huang, Chi-Ying F. Shiao, Young-Ji Ching, Tsui-Ting |
author_sort | Chen, Yan-Xi |
collection | PubMed |
description | Declines in physiological functions are the predominant risk factors for age-related diseases, such as cancers and neurodegenerative diseases. Therefore, delaying the aging process is believed to be beneficial in preventing the onset of age-related diseases. Previous studies have demonstrated that Graptopetalum paraguayense (GP) extract inhibits liver cancer cell growth and reduces the pathological phenotypes of Alzheimer’s disease (AD) in patient IPS-derived neurons. Here, we show that GP extract suppresses β-amyloid pathology in SH-SYS5Y-APP(695) cells and APP/PS1 mice. Moreover, AMP-activated protein kinase (AMPK) activity is enhanced by GP extract in U87 cells and APP/PS1 mice. Intriguingly, GP extract enhances autophagy in SH-SYS5Y-APP(695) cells, U87 cells, and the nematode Caenorhabditis elegans, suggesting a conserved molecular mechanism by which GP extract might regulate autophagy. In agreement with its role as an autophagy activator, GP extract markedly diminishes mobility decline in polyglutamine Q35 mutants and aged wild-type N2 animals in C. elegans. Furthermore, GP extract significantly extends lifespan in C. elegans. |
format | Online Article Text |
id | pubmed-8706064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87060642021-12-25 Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems Chen, Yan-Xi Le, Phuong Thu Nguyen Tzeng, Tsai-Teng Tran, Thu-Ha Nguyen, Anh Thuc Cheng, Irene Han-Juo Huang, Chi-Ying F. Shiao, Young-Ji Ching, Tsui-Ting Nutrients Article Declines in physiological functions are the predominant risk factors for age-related diseases, such as cancers and neurodegenerative diseases. Therefore, delaying the aging process is believed to be beneficial in preventing the onset of age-related diseases. Previous studies have demonstrated that Graptopetalum paraguayense (GP) extract inhibits liver cancer cell growth and reduces the pathological phenotypes of Alzheimer’s disease (AD) in patient IPS-derived neurons. Here, we show that GP extract suppresses β-amyloid pathology in SH-SYS5Y-APP(695) cells and APP/PS1 mice. Moreover, AMP-activated protein kinase (AMPK) activity is enhanced by GP extract in U87 cells and APP/PS1 mice. Intriguingly, GP extract enhances autophagy in SH-SYS5Y-APP(695) cells, U87 cells, and the nematode Caenorhabditis elegans, suggesting a conserved molecular mechanism by which GP extract might regulate autophagy. In agreement with its role as an autophagy activator, GP extract markedly diminishes mobility decline in polyglutamine Q35 mutants and aged wild-type N2 animals in C. elegans. Furthermore, GP extract significantly extends lifespan in C. elegans. MDPI 2021-11-29 /pmc/articles/PMC8706064/ /pubmed/34959868 http://dx.doi.org/10.3390/nu13124317 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Yan-Xi Le, Phuong Thu Nguyen Tzeng, Tsai-Teng Tran, Thu-Ha Nguyen, Anh Thuc Cheng, Irene Han-Juo Huang, Chi-Ying F. Shiao, Young-Ji Ching, Tsui-Ting Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title | Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title_full | Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title_fullStr | Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title_full_unstemmed | Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title_short | Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems |
title_sort | graptopetalum paraguayense extract ameliorates proteotoxicity in aging and age-related diseases in model systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706064/ https://www.ncbi.nlm.nih.gov/pubmed/34959868 http://dx.doi.org/10.3390/nu13124317 |
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