Cargando…

A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression

Prostate cancer (PCa) is the major cause of cancer-related death in males; however, effective treatments to prevent aggressive progression remain an unmet need. We have previously demonstrated that secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a multifunctional innate imm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Belinda L., Tang, Lin, Sun, Xiaoguang, Garcia, Alexander N., Camp, Sara M., Posadas, Edwin, Cress, Anne E., Garcia, Joe G. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706080/ https://www.ncbi.nlm.nih.gov/pubmed/34959723 http://dx.doi.org/10.3390/ph14121322

Ejemplares similares

Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target
por: Sun, Belinda L, et al.
Publicado: (2020)

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine
por: Grolla, Ambra A, et al.
Publicado: (2016)

Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker
por: Semerena, Elise, et al.
Publicado: (2023)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer
por: Travelli, Cristina, et al.
Publicado: (2023)

Expression of Nicotinamide Phosphoribosyltransferase-Influenced Genes Predicts Recurrence-Free Survival in Lung and Breast Cancers
por: Zhou, Tong, et al.
Publicado: (2014)

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
por: Karpov, Alexei S., et al.
Publicado: (2018)

Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves’ opthalmopathy
por: Sawicka-Gutaj, Nadia, et al.
Publicado: (2016)

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
por: Zhang, Li Q, et al.
Publicado: (2017)

Cerebral Ischemia Is Exacerbated by Extracellular Nicotinamide Phosphoribosyltransferase via a Non-Enzymatic Mechanism
por: Zhao, Bing, et al.
Publicado: (2013)

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma
por: Hara, Nobumasa, et al.
Publicado: (2011)

Nicotinamide phosphoribosyltransferase regulates the cell differentiation and mineralization in cultured odontoblasts
por: Kang, Kyeong-Rok, et al.
Publicado: (2022)

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
por: Colombo, Giorgia, et al.
Publicado: (2022)

Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro
por: Funk, RS, et al.
Publicado: (2016)

Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases
por: Liu, Li-Ying, et al.
Publicado: (2012)

Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer
por: Zhang, Kui, et al.
Publicado: (2014)

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors
por: Tanuma, Sei-ichi, et al.
Publicado: (2020)

Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process
por: Khaidizar, Fiqri D., et al.
Publicado: (2021)

Nicotinamide phosphoribosyltransferase as a biomarker for the diagnosis of infectious pleural effusions
por: Huang, Jing, et al.
Publicado: (2021)

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies
por: Biniecka, Paulina, et al.
Publicado: (2023)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
por: Audrito, Valentina, et al.
Publicado: (2018)

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
por: Xu, Tian-Ying, et al.
Publicado: (2015)

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
por: Sadrerafi, Keivan, et al.
Publicado: (2018)

Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase
por: Ling, Min, et al.
Publicado: (2017)

Changes of Nicotinamide Phosphoribosyltransferase Expressions in Thyroid Glands of Patients with Different Thyroid Pathologies
por: Sawicka-Gutaj, Nadia, et al.
Publicado: (2018)

Nicotinamide phosphoribosyltransferase-related signaling pathway in early Alzheimer's disease mouse models
por: Xing, Sanli, et al.
Publicado: (2019)

SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase
por: Higgins, Cassandra B., et al.
Publicado: (2022)

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis
por: Sun, Xu, et al.
Publicado: (2023)

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway
por: Feng, Duo, et al.
Publicado: (2020)

Extracellular Nicotinamide Phosphoribosyltransferase as a Surrogate Marker of Prominent Malignant Potential in Colonic Polyps: A 2-Year Prospective Study
por: Chen, Tsung-Hsing, et al.
Publicado: (2023)

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase
por: Olesen, Uffe H, et al.
Publicado: (2010)

Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells
por: Tolstikov, Vladimir, et al.
Publicado: (2014)

Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
por: Ogino, Yoko, et al.
Publicado: (2018)

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
por: LoCoco, Peter M, et al.
Publicado: (2017)

MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase
por: Gao, Hui, et al.
Publicado: (2019)

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4
por: Gasparrini, Massimiliano, et al.
Publicado: (2022)

Serum nicotinamide phosphoribosyltransferase as a novel biomarker for non-traumatic osteonecrosis of the femoral head
por: Wang, Shiying, et al.
Publicado: (2022)

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
por: Conforti, Irene, et al.
Publicado: (2023)

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
por: Yammani, Raghunatha R, et al.
Publicado: (2012)

Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD(+)–Sirt1 signaling
por: Pi, Chenchen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0es8dnl3f7qglfct90jtcquelq