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Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of m...

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Autores principales: Udovicic, Ivo, Stanojevic, Ivan, Djordjevic, Dragan, Zeba, Snjezana, Rondovic, Goran, Abazovic, Tanja, Lazic, Srdjan, Vojvodic, Danilo, To, Kendrick, Abazovic, Dzihan, Khan, Wasim, Surbatovic, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706110/
https://www.ncbi.nlm.nih.gov/pubmed/34945111
http://dx.doi.org/10.3390/jcm10245815
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author Udovicic, Ivo
Stanojevic, Ivan
Djordjevic, Dragan
Zeba, Snjezana
Rondovic, Goran
Abazovic, Tanja
Lazic, Srdjan
Vojvodic, Danilo
To, Kendrick
Abazovic, Dzihan
Khan, Wasim
Surbatovic, Maja
author_facet Udovicic, Ivo
Stanojevic, Ivan
Djordjevic, Dragan
Zeba, Snjezana
Rondovic, Goran
Abazovic, Tanja
Lazic, Srdjan
Vojvodic, Danilo
To, Kendrick
Abazovic, Dzihan
Khan, Wasim
Surbatovic, Maja
author_sort Udovicic, Ivo
collection PubMed
description Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature.
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spelling pubmed-87061102021-12-25 Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19 Udovicic, Ivo Stanojevic, Ivan Djordjevic, Dragan Zeba, Snjezana Rondovic, Goran Abazovic, Tanja Lazic, Srdjan Vojvodic, Danilo To, Kendrick Abazovic, Dzihan Khan, Wasim Surbatovic, Maja J Clin Med Review Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature. MDPI 2021-12-12 /pmc/articles/PMC8706110/ /pubmed/34945111 http://dx.doi.org/10.3390/jcm10245815 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Udovicic, Ivo
Stanojevic, Ivan
Djordjevic, Dragan
Zeba, Snjezana
Rondovic, Goran
Abazovic, Tanja
Lazic, Srdjan
Vojvodic, Danilo
To, Kendrick
Abazovic, Dzihan
Khan, Wasim
Surbatovic, Maja
Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title_full Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title_fullStr Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title_full_unstemmed Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title_short Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19
title_sort immunomonitoring of monocyte and neutrophil function in critically ill patients: from sepsis and/or trauma to covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706110/
https://www.ncbi.nlm.nih.gov/pubmed/34945111
http://dx.doi.org/10.3390/jcm10245815
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