Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild ma...

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Detalles Bibliográficos
Autores principales: Favre, Guillaume, Mazzetti, Sara, Gengler, Carole, Bertelli, Claire, Schneider, Juliane, Laubscher, Bernard, Capoccia, Romina, Pakniyat, Fatemeh, Ben Jazia, Inès, Eggel-Hort, Béatrice, de Leval, Laurence, Pomar, Léo, Greub, Gilbert, Baud, David, Giannoni, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706116/
https://www.ncbi.nlm.nih.gov/pubmed/34960786
http://dx.doi.org/10.3390/v13122517
Descripción
Sumario:Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.

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