Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild ma...

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Autores principales: Favre, Guillaume, Mazzetti, Sara, Gengler, Carole, Bertelli, Claire, Schneider, Juliane, Laubscher, Bernard, Capoccia, Romina, Pakniyat, Fatemeh, Ben Jazia, Inès, Eggel-Hort, Béatrice, de Leval, Laurence, Pomar, Léo, Greub, Gilbert, Baud, David, Giannoni, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706116/
https://www.ncbi.nlm.nih.gov/pubmed/34960786
http://dx.doi.org/10.3390/v13122517
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author Favre, Guillaume
Mazzetti, Sara
Gengler, Carole
Bertelli, Claire
Schneider, Juliane
Laubscher, Bernard
Capoccia, Romina
Pakniyat, Fatemeh
Ben Jazia, Inès
Eggel-Hort, Béatrice
de Leval, Laurence
Pomar, Léo
Greub, Gilbert
Baud, David
Giannoni, Eric
author_facet Favre, Guillaume
Mazzetti, Sara
Gengler, Carole
Bertelli, Claire
Schneider, Juliane
Laubscher, Bernard
Capoccia, Romina
Pakniyat, Fatemeh
Ben Jazia, Inès
Eggel-Hort, Béatrice
de Leval, Laurence
Pomar, Léo
Greub, Gilbert
Baud, David
Giannoni, Eric
author_sort Favre, Guillaume
collection PubMed
description Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
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spelling pubmed-87061162021-12-25 Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury Favre, Guillaume Mazzetti, Sara Gengler, Carole Bertelli, Claire Schneider, Juliane Laubscher, Bernard Capoccia, Romina Pakniyat, Fatemeh Ben Jazia, Inès Eggel-Hort, Béatrice de Leval, Laurence Pomar, Léo Greub, Gilbert Baud, David Giannoni, Eric Viruses Case Report Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia. MDPI 2021-12-15 /pmc/articles/PMC8706116/ /pubmed/34960786 http://dx.doi.org/10.3390/v13122517 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Favre, Guillaume
Mazzetti, Sara
Gengler, Carole
Bertelli, Claire
Schneider, Juliane
Laubscher, Bernard
Capoccia, Romina
Pakniyat, Fatemeh
Ben Jazia, Inès
Eggel-Hort, Béatrice
de Leval, Laurence
Pomar, Léo
Greub, Gilbert
Baud, David
Giannoni, Eric
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title_full Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title_fullStr Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title_full_unstemmed Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title_short Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
title_sort decreased fetal movements: a sign of placental sars-cov-2 infection with perinatal brain injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706116/
https://www.ncbi.nlm.nih.gov/pubmed/34960786
http://dx.doi.org/10.3390/v13122517
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